Protein Alignment CG10486 and SLC22A4

DIOPT Version :9

• Sequence 1: NP_647998.2
• Gene: CG10486 / 38664
• FlyBaseID: FBgn0035647
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 144/619 - (23%)
• Similarity: 254/619 - (41%)
• Gaps: 113/619 - (18%)

  Fly    95 DFDDLLPMIGQFGRFQIRLFLFMIPFCFI-TAFVYLGQIFMCLTPPKYYCYVPELLH-------- 150
            |:|:::..:|::|.|| ||..|::....| ..|..:..:|:..| |::.|.||:..:
Human     3 DYDEVIAFLGEWGPFQ-RLIFFLLSASIIPNGFNGMSVVFLAGT-PEHRCRVPDAANLSSAWRNN 65

  Fly   151 -TPVELRKELSIPKEKDGSYSRCRMYN-TNYTKIHFAENPSAYINT-SLPTIPCKKGYVFEQEGR 212
             .|:.||....:|.    |.||.|:.. .|::.:..  .|...::. .|....|..|:.|.|: .
Human    66 SVPLRLRDGREVPH----SCSRYRLATIANFSALGL--EPGRDVDLGQLEQESCLDGWEFSQD-V 123

  Fly   213 AFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATS 277
            ...:...|:..:|:|:........:||:|.:||....|..:|..||...|.::..:....|....
Human   124 YLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQI 188

  Fly   278 MSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSA 342
            .|..:..|.:...:||....:.:.:.:||..|.:|...|.:.:.|.:..|::...|::|..|...
Human   189 FSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFI 253

  Fly   343 GNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEA 407
            .:||......::|.||.:..:..:|||.|||:|.....:|.:|::...::|...|...|.|..|.
Human   254 RDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEE 318

  Fly   408 SCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENI----FL 468
                  ...|..:...:|.:|:.:.:|...|:.:|:||..|:.|     .|..||:.|:    :|
Human   319 ------LNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGY-----FALSLDAPNLHGDAYL 372

  Fly   469 FFTIACATELPGNILVILTLDRAGRRW--------------------CSFFYTSLSGVFSLLGAS 513
            ...::...|:|..|...|.|....||:                    ..:::.|:..|
Human   373 NCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLV------- 430

  Fly   514 FQNRANMRMSALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKK 578
                       :.|:|.....:::...:.||:.||:||...|....|...|..:::|..|||...
Human   431 -----------MLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAY 484

  Fly   579 SLSSTLIVLGALGIFGGLLALFLPETLNHELPETLSDGAQFGKNQRIWHMPCCGPGSRKSHPRHN 643
            :.....||:|:|.:..|:|.||.||:|...|||||.      :.|::                 .
Human   485 NRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLE------QMQKV-----------------K 526

  Fly   644 WHQGSSLRTLSKDEFRSSKMYRKTKYRFESHPSP 677
            |             |||.|   ||:...|:..:|
Human   527 W-------------FRSGK---KTRDSMETEENP 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	129/543 (24%)
		MFS	231..602	CDD:119392	91/394 (23%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	129/543 (24%)
		MFS	123..508	CDD:119392	94/413 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153716
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850