Protein Alignment CG10486 and SLC22A3

DIOPT Version :9

• Sequence 1: NP_647998.2
• Gene: CG10486 / 38664
• FlyBaseID: FBgn0035647
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 165/580 - (28%)
• Similarity: 274/580 - (47%)
• Gaps: 64/580 - (11%)

  Fly    96 FDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELL----------- 149
            ||:.|..:|:|||||.|:||.:.......||:::|.:|:...|..|:|..|...
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPE 68

  Fly   150 -----HTPVELRKELSIPKEKDGSYSRCRMY-------NTNYTKIHFAENP-SAYINTSLPTIPC 201
                 ..|.....|   |.|:.|   ||:.|       :.:.|......:| :|:.|.|.|.:||
Human    69 EEWNRTAPASRGPE---PPERRG---RCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPC 127

  Fly   202 KKGYVFEQEGRAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSC 266
            :.|:.:.|   |..:...||..:|.:.......|.|..||.:.|....|:.||..||:...:.||
Human   128 RGGWRYAQ---AHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSC 189

  Fly   267 FLALVGSLATSMSTDFFTFAISRFLVG----ASYDTCFTMVYILVLEYVGPKYRTLVANLSLALF 327
            ....|..:..:.:.:|..|.|.|||.|    .::.||    |::|.|.||.|.|.:| .:.:.:|
Human   190 LGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTC----YVIVTEIVGSKQRRIV-GIVIQMF 249

  Fly   328 YSPFTMVMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEV 392
            ::...:::|.||....||:......:||..|.:..:.::|||.|||::..:.||||:||:.:.:.
Human   250 FTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKC 314

  Fly   393 NKKQVSKEILDLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRA 457
            |.|.:|.   :..|.:.|.   ||:....|  |.:.:..:|.:..::::..|.:.::||.|.|..
Human   315 NGKYLSS---NYSEITVTD---EEVSNPSF--LDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMR 371

  Fly   458 ASVLDSENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASF-QNRANMR 521
            ..::.. |:::.|.|:...||||.:|::||::|.|||........::||..|:.|.. :..|.:|
Human   372 LGIIGG-NLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLR 435

  Fly   522 MS-ALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVY-LSKKSLSSTL 584
            .: |..||....:.:.|.....:|:.||.:|..||:....:.....:::|.::: |:...|...|
Human   436 TTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPL 500

  Fly   585 IVLGALGIFGGLLALFLPETLNHELPETLSDGAQFGKNQRIWHMPCCG-----PGSRKSH 639
            |:.|.|....|.|.:.||||....||||:.|..:.|..    |...||     |.|| ||
Human   501 IIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSP----HSCKCGRNKKTPVSR-SH 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	150/538 (28%)
		MFS	231..602	CDD:119392	105/377 (28%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	150/538 (28%)
		MFS	149..518	CDD:119392	105/382 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850