Protein Alignment CG10486 and SLC22A3

DIOPT Version :10

• Sequence 1: NP_647998.2
• Gene: CG10486 / 38664
• FlyBaseID: FBgn0035647
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 165/580 - (28%)
• Similarity: 274/580 - (47%)
• Gaps: 64/580 - (11%)

  Fly    96 FDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELL----------- 149
            ||:.|..:|:|||||.|:||.:.......||:::|.:|:...|..|:|..|...
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPE 68

  Fly   150 -----HTPVELRKELSIPKEKDGSYSRCRMY-------NTNYTKIHFAENP-SAYINTSLPTIPC 201
                 ..|.....|   |.|:.|   ||:.|       :.:.|......:| :|:.|.|.|.:||
Human    69 EEWNRTAPASRGPE---PPERRG---RCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPC 127

  Fly   202 KKGYVFEQEGRAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSC 266
            :.|:.:.|   |..:...||..:|.:.......|.|..||.:.|....|:.||..||:...:.||
Human   128 RGGWRYAQ---AHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSC 189

  Fly   267 FLALVGSLATSMSTDFFTFAISRFLVG----ASYDTCFTMVYILVLEYVGPKYRTLVANLSLALF 327
            ....|..:..:.:.:|..|.|.|||.|    .::.||    |::|.|.||.|.|.:| .:.:.:|
Human   190 LGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTC----YVIVTEIVGSKQRRIV-GIVIQMF 249

  Fly   328 YSPFTMVMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEV 392
            ::...:::|.||....||:......:||..|.:..:.::|||.|||::..:.||||:||:.:.:.
Human   250 FTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKC 314

  Fly   393 NKKQVSKEILDLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRA 457
            |.|.:|.   :..|.:.|.   ||:....|  |.:.:..:|.:..::::..|.:.::||.|.|..
Human   315 NGKYLSS---NYSEITVTD---EEVSNPSF--LDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMR 371

  Fly   458 ASVLDSENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASF-QNRANMR 521
            ..::.. |:::.|.|:...||||.:|::||::|.|||........::||..|:.|.. :..|.:|
Human   372 LGIIGG-NLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLR 435

  Fly   522 MS-ALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVY-LSKKSLSSTL 584
            .: |..||....:.:.|.....:|:.||.:|..||:....:.....:::|.::: |:...|...|
Human   436 TTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPL 500

  Fly   585 IVLGALGIFGGLLALFLPETLNHELPETLSDGAQFGKNQRIWHMPCCG-----PGSRKSH 639
            |:.|.|....|.|.:.||||....||||:.|..:.|..    |...||     |.|| ||
Human   501 IIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSP----HSCKCGRNKKTPVSR-SH 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	150/538 (28%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	150/538 (28%)
		Proline-rich sequence. /evidence=ECO:0000305|PubMed:26979622	289..293		3/3 (100%)