Protein Alignment CG10486 and SLC22A1

DIOPT Version :9

• Sequence 1: NP_647998.2
• Gene: CG10486 / 38664
• FlyBaseID: FBgn0035647
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 129/536 - (24%)
• Similarity: 231/536 - (43%)
• Gaps: 74/536 - (13%)

  Fly    97 DDLLPMIGQFGRFQIRLFLFMIPFCFITAF---VYLGQIFMCLTPPKYYCYVPELLHTPVELRKE 158
            ||:|..:|:.|.||.:.||.:   |.::|.   :.:|.:|:..| |.::|..|.:    .||.:.
Human     5 DDILEQVGESGWFQKQAFLIL---CLLSAAFAPICVGIVFLGFT-PDHHCQSPGV----AELSQR 61

  Fly   159 LSIPKEKDGSYS-------------RCRMYNTNYTKIHFA-ENPSAYINTS---LPTIPCKKGYV 206
            ......::.:|:             :||.|..::.:...: .:|.|.:.|:   ||..||:.|:|
Human    62 CGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWV 126

  Fly   207 FEQEGRAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALV 271
            ::..|   .|...||..:|.|.......|.....|.:.|.|..|:|||..||...|:.:..:..|
Human   127 YDTPG---SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAV 188

  Fly   272 GSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFT---M 333
            ..:..:.|.::.:..:.|.|.|......:...|.|:.|:||...|..||    .::...||   :
Human   189 SGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVA----IMYQMAFTVGLV 249

  Fly   334 VMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVS 398
            .:..:|.:..:||......|||..|.:..:..:|||.|||:|.....:|::|:.::.:.|.|...
Human   250 ALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPP 314

  Fly   399 KEILDLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDG---HVRAASV 460
               .||...|..:...|:|..   :...:|:..|:.:...:::.:|.:.|::|.|   |:.|.
Human   315 ---ADLKMLSLEEDVTEKLSP---SFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGAT-- 371

  Fly   461 LDSENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSG------VFSLLGASFQNRAN 519
              |.|::|.|..:...|:||..:.::|:||.||.:.......|:|      :|......:.|...
Human   372 --SGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIII 434

  Fly   520 MRMSALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSP-------------P 571
            |    ..||....|...:.....||:.||.||..||....::..:..:::|             |
Human   435 M----CVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALP 495

  Fly   572 VVYLSKKSLSSTLIVL 587
            ::...|:|...|...|
Human   496 LILFEKQSPKKTRFTL 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	126/529 (24%)
		MFS	231..602	CDD:119392	91/382 (24%)
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	122/515 (24%)
		MFS	118..484	CDD:119392	96/386 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153745
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950