Protein Alignment CG10486 and SLC22A23

DIOPT Version :9

• Sequence 1: NP_647998.2
• Gene: CG10486 / 38664
• FlyBaseID: FBgn0035647
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: XP_011513103.1
• Gene: SLC22A23 / 63027
• HGNCID: 21106
• Length: 710
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 132/633 - (20%)
• Similarity: 231/633 - (36%)
• Gaps: 141/633 - (22%)

  Fly    94 IDFD-DLLPMIGQF-GRFQIRLFLF-MIPFCFITAFVYLGQIFMCLTPPKYYC------------ 143
            :|:| .:||.:|.. |.:|..|.|. .||..|| .|......|: |..|.::|
Human    78 LDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFI-GFSQFSDSFL-LDQPNFWCRGAGKGTELAGV 140

  Fly   144 ----------YVPELLHTPVELRKELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPT 198
                      ....|..||.     .:.|.|..|:.|       |.:.....:.|      .||:
Human   141 TTTGRGGDMGNWTSLPTTPF-----ATAPWEAAGNRS-------NSSGADGGDTP------PLPS 187

  Fly   199 IPCKKGYVFEQEGRAF--------------------ESATM-----------EFGW--LCDDDKY 230
            .|.|.......:.||:                    |:..:           |..|  :||:...
Human   188 PPDKGDNASNCDCRAWDYGIRAGLVQNVVSKCCQQQETGALPWDTDTKRWRPELNWDLVCDNAWK 252

  Fly   231 ATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFTFAISRFLVGAS 295
            ...|:....:|.|.|.|..|..||..||...|:.|....|:..|..::|.:...|:..||..|..
Human   253 VHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFC 317

  Fly   296 YDTCFTMVYILVLEYVGPKYR---TLVANLSLALFYSPFTMVMPWIALSAGNWRRFSSFTSLPIV 357
            .......:|.|.:|...|..|   |:||  |.......|  :||.:|....:|:...:....|.:
Human   318 LAGIILTLYALRIELCPPGKRFMITMVA--SFVAMAGQF--LMPGLAALCRDWQVLQALIICPFL 378

  Fly   358 LAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASCTQFYKEELDGRDF 422
            |.:..:.:.|||.|||::..:.:.|..::.:..:.|:.....:|..:...     .::||.
Human   379 LMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIPE-----LEKELS---- 434

  Fly   423 TVLSIFKRKRMARYMILMIL----IWMSI------SLVYDG--HVRAASVLDS-------ENIFL 468
                    :|..:..|:.::    :|.:|      ||...|  |..|.|::..       ||.:.
Human   435 --------RRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYA 491

  Fly   469 FFTIACATELPGNILVILTLDRAGRRWCSFFYTSLS--------GVFSLLGASFQNRANMRMS-- 523
            .:....:..|...:.:.:.:...|||.....:..|:        |:.:|:| .:....:..||
Human   492 DYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIG-KYSQHPDSGMSDS 555

  Fly   524 ---------ALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKS 579
                     ::.|.|.|:...::.:.:.|||.|||:|..|:..:.......||.:|.:...::|.
Human   556 VKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKG 620

  Fly   580 LSSTLIVLGALGIFGGLLALFLPETLNHELPETLSDGAQFGKNQRIWH 627
            .....|:.....:...:..|.|||:.:..|||.:|:|..:.:...:.|
Human   621 YFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPLLPH 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	124/605 (20%)
		MFS	231..602	CDD:119392	85/411 (21%)
SLC22A23	XP_011513103.1	2A0119	<243..652	CDD:273328	92/430 (21%)
		MFS	259..>388	CDD:119392	34/132 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940