Protein Alignment CG10486 and sv2ca

DIOPT Version :9

• Sequence 1: NP_647998.2
• Gene: CG10486 / 38664
• FlyBaseID: FBgn0035647
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_001121811.1
• Gene: sv2ca / 562345
• ZFINID: ZDB-GENE-060526-233
• Length: 745
• Species: Danio rerio
• Alignment Length: 823
• Identity: 155/823 - (18%)
• Similarity: 245/823 - (29%)
• Gaps: 357/823 - (43%)

  Fly    12 EDDDKPKKREHRDQGQQSKLKKIKYYIEPDKVDIGIQAGDSLEKVKVTYVEPDDEESSHGFF--- 73
            ||||                    ||.:||......||.|.......|....|::|...|.:
Zfish    54 EDDD--------------------YYSQPDGNYTSHQANDEEGSSDATEGHDDEDEIYEGEYQGI 98

  Fly    74 ------------WGKKKSETSLPRRSWETDDYIDFDDL---LPMIGQ---FGRFQIRLFLFMIPF 120
                        .|:..|:....||..|.:...|.::|   ..:|.|   .||||.:|| |.:..
Zfish    99 PSDAKARDGQVALGQPLSDGLKDRRELENERQADEEELAQQYELIIQECGHGRFQWQLF-FTLGL 162

  Fly   121 C--------FITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKELSIPKEKDGSYSRCRMYNT 177
            .        |:..||.
Zfish   163 ALMSDGVEVFVVGFVL------------------------------------------------- 178

  Fly   178 NYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAFESATMEFGWLCDDDKYATYAQIIFFLGS 242
                      |||..:..:|                 :|::   |||..          |.:||.
Zfish   179 ----------PSAETDMCVP-----------------DSSS---GWLGS----------IVYLGM 203

  Fly   243 ILGGLAYGHFADHCGRVAALVSSCFLALVGSLA--TSMSTDFFTFAISRFLVGASYDTCFTMVY- 304
            ::|...:|..||..||...|: .| ::|.|..|  :|....:..|.:.|.:.|........:|:
Zfish   204 MVGAFFWGGMADKVGRRQCLL-IC-MSLNGFFAFLSSFVQGYGLFLLCRMIAGFGIGGAVPIVFS 266

  Fly   305 ----ILVLEYVG-------------------------PKYRTLVANLSLALFYSPFTMVMPWIAL 340
                :|..|..|                         |.|..:....|..:.|..:|   .| :.
Zfish   267 YFAEVLAREKRGEHLSWLCMFWMIGEIYASAMAWAIIPHYGQITTASSQFINYHHYT---SW-SF 327

  Fly   341 SAG------NWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILK------------ 387
            |.|      :||.|....:||.|.|:.:...:|||.|:.:.||:.|:|..|||
Zfish   328 SMGSAYQFHSWRVFVVVCALPCVCAVVALTFMPESPRFYLEVGKHDEAWMILKQIHDTNMRARGQ 392

  Fly   388 --NVIEVNKKQVSKEI---LDLFEASCTQFY-------KEELDGRDFTVLSIFKRKRMARYMILM 440
              .|..||:.::.|:|   :::.|:.  .|:       |.||.|.....|..|... :....:.:
Zfish   393 PEKVFTVNRIKIPKQIDEFVEMHESG--NFFSKAIFRIKTELHGIWLNFLKCFNYP-VKESTVKL 454

  Fly   441 ILIWMSISLVY----------------DGHVRAASVLDSENI--FLF-FTI-------------- 472
            .::|:::|..|                |.:.......::|.|  |.| ||:
Zfish   455 AIVWLTLSFGYYGLSVWFPDVIKHLQNDEYASKGQRHNNERIEDFTFNFTLENQIHTNSLFINDR 519

  Fly   473 -----------------ACATE------------------------------------------- 477
                             :|..|
Zfish   520 FINMKFKSVTFINSTFQSCFFEDVTSVGSFFRNCTFIEAVFYNTDIDDSKLKNTDVINSTFYHNK 584

  Fly   478 ---------------------------LPGNILVILTLDRAGRRWCSFFYTSLSGV---FSLLGA 512
                                       |||||:..|.:|:.||.....|...|||:   |...|.
Zfish   585 TGCQMTFEDDYSAYWVYFVNFLGTLAVLPGNIVSALLMDKIGRLSMLGFSMILSGISCFFLWFGT 649

  Fly   513 SFQNRANMRMSALAGRFFSNICYNIGLQWAA---------EILPTVVRAQGVAFIHTMGFVAMLM 568
            |......|            :|...||..:|         |:.||..|..|..|.:.:..:|.:|
Zfish   650 SESMMIGM------------LCLYNGLSISAWNSLDVVTTELYPTDRRGTGFGFCNALCKLAAVM 702

  Fly   569 SPPVVYLSKKSLSSTLIVLGALGIF--GGLLALFLPETLNHEL 609
            . .:::.|...::..:.:|.|..:.  |||:.|.||:|.::.|
Zfish   703 G-NLIFGSLVGITKAIPILLASSVLVGGGLVGLRLPDTRSNVL 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	132/713 (19%)
		MFS	231..602	CDD:119392	109/566 (19%)
sv2ca	NP_001121811.1	synapt_SV2	3..745	CDD:130366	155/823 (19%)
		Spt5_N	73..>141	CDD:288770	12/67 (18%)
		MFS	157..>360	CDD:119392	50/298 (17%)
		MFS	588..>711	CDD:119392	30/135 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910