DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and slc22a13b

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	XP_017209322.1	Gene:	slc22a13b / 556601	ZFINID:	ZDB-GENE-061013-532	Length:	549	Species:	Danio rerio

Alignment Length:	534	Identity:	159/534 - (29%)
Similarity:	257/534 - (48%)	Gaps:	43/534 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 IDFDDLLPMIGQFGRFQIRLFLFM-IPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRK 157
            |||..:|..:|:||.||.||.:.: :|..| |||...||:|..::.| :||....:|.....|.:
Zfish     2 IDFTQILSSVGEFGAFQKRLLVAVCLPNIF-TAFHMFGQVFTAISFP-HYCNSSWILRQAPNLTE 64

  Fly   158 E----LSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAFESAT 218
            |    |::|.:..|.|..|:|:......|...|:..  |||   |..|..|:|::...   :|:|
Zfish    65 EKQLNLTVPLDSKGQYESCKMFTPVEMDIEDIEHYG--INT---TTSCIDGWVYKAPK---DSST 121

  Fly   219 M--EFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTD 281
            :  ||..:|::..|:..:|.|:..|.::|.|.:|..||..||..|.:.|.||..:..:..:.|.:
Zfish   122 LITEFDLVCENKVYSEASQSIYMAGLLVGALLFGPMADKYGRRFATLLSLFLQFLSGVGVAFSPN 186

  Fly   282 FFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWR 346
            .:.:...||:||.:........::|..|:.|...|.|...|| ..|::...|::..:|....|||
Zfish   187 IYVYIALRFVVGTTISGISINTFVLGTEWCGSAKRALFTILS-HCFFAIGLMLLSGVAYGIRNWR 250

  Fly   347 RFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKA-LEILKNVIEVNKKQVSKEILDLFEASCT 410
            ......|.|:.|....:.:||||||||::.|::|.| .|||| ...:|.::||:.:||..||..|
Zfish   251 VLQLVLSAPVGLFFIYYWILPESARWLLTQGKLDSAKREILK-AARINGRKVSENLLDKMEAENT 314

  Fly   411 QFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASV------LDSENIFLF 469
                    .:..|::.:|:...:.:..::|..:|...||||.|    .|:      ||   |:|.
Zfish   315 --------AKSSTMIDLFRVGYLRKRALIMCYMWFVTSLVYYG----VSLNVGNFGLD---IYLT 364

  Fly   470 FTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASFQNRANMRMSALA--GRFFSN 532
            ..|....|.|..:.....:.|.|||.|......|.|...|:..:...:..:.::.:|  |:|...
Zfish   365 QLIFGMAEFPARLSCFPLIQRFGRRICQSVVLLLGGTACLIIPAIPAKYPIVVTVIAVIGKFSLA 429

  Fly   533 ICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLL 597
            ..::|...:.||:.|||||..||........||.:::|.:..|.....:..:|:.|:|...||.|
Zfish   430 ASFSIVYVYTAELYPTVVRQNGVGLNSMCARVAGILAPLIGLLDVYHHAIPMIIYGSLPFVGGAL 494

  Fly   598 ALFLPETLNHELPE 611
            ...||||||.:|.:
Zfish   495 TFLLPETLNTDLQD 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	155/524 (30%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	106/379 (28%)
slc22a13b	XP_017209322.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850