DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10486 and SLC22A15

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_060890.2	Gene:	SLC22A15 / 55356	HGNCID:	20301	Length:	547	Species:	Homo sapiens

Alignment Length:	547	Identity:	126/547 - (23%)
Similarity:	228/547 - (41%)	Gaps:	77/547 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 IDFDDLLPMIGQFGRFQIRLFLFMIPFCFITA-----FVYLGQIFMCL--TPPKYYCYVPELLHT 151
            ::.::....:|:.|.:|:.|       ||:.|     :|....|.:.|  ..|.|:..:.|||
Human     1 MEVEEAFQAVGEMGIYQMYL-------CFLLAVLLQLYVATEAILIALVGATPSYHWDLAELL-- 56

  Fly   152 PVELRKELSIPKEKDGSYSRCR-------MYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQ 209
                      |.:..|:.|...       :...|.::||      .:::.|
Human    57 ----------PNQSHGNQSAGEDQAFGDWLLTANGSEIH------KHVHFS-------------- 91

  Fly   210 EGRAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSL 274
              .:|.|...|:..:.:.....:.|...||.|..:|.:::|..:|..||....::...|.::.::
Human    92 --SSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAI 154

  Fly   275 ATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIA 339
            |...|..:..||::|||||........:.::|:.|.||..|..|..::. .||::........:.
Human   155 ANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIG-GLFFAVGIAQYALLG 218

  Fly   340 LSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKK-QVSKEILD 403
            ....:||..:...:|...:.......:|||.|||.|.|.:.:|.|.|..:.:.|:| :.:..:..
Human   219 YFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTH 283

  Fly   404 LFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIFL 468
            ....||.:         ..:.|.:|:.:.:..:.::::.||...||||.|...:|..|.. :|:.
Human   284 PANRSCRE---------TGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGG-SIYA 338

  Fly   469 FFTIACATELPGNILVILTLDRA--GRRWCSFFYTSLSGVFSLLGASFQNR--------ANMRMS 523
            ...::...|:|...|.|..:::.  ||:.....:..|.|:..|:......:        .|....
Human   339 NLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSL 403

  Fly   524 ALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLG 588
            :|.|:...:..:||...:.:|:.|||:|..|:........|..:::|.:..|.....|...||.|
Human   404 SLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFG 468

  Fly   589 ALGIFGGLLALFLPETLNHELPETLSD 615
            |.|:..|||:|.||||||..|.||.||
Human   469 ATGLTSGLLSLLLPETLNSPLLETFSD 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	122/532 (23%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	90/381 (24%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	83/368 (23%)
		MFS_1	111..450	CDD:284993	78/349 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153630
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850