DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and SLC22A17

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_065105.3	Gene:	SLC22A17 / 51310	HGNCID:	23095	Length:	649	Species:	Homo sapiens

Alignment Length:	614	Identity:	141/614 - (22%)
Similarity:	222/614 - (36%)	Gaps:	121/614 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 IDFDDLLPMIGQF-GRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRK 157
            :.|:.||..:|.. |..|::|.|..:|..|:...:....|| .|.|| .:|:..
Human    78 LSFEALLAQVGALGGGQQLQLGLCCLPVLFVALGMASDPIF-TLAPP-LHCHYG----------- 129

  Fly   158 ELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIP------------CKKGYVFEQE 210
              :.|....|..........:......|.:.::.:.||  |.|            |.|.:.:...
Human   130 --AFPPNASGWEQPPNASGVSVASAALAASAASRVATS--TDPSCSGFAPPDFNHCLKDWDYNGL 190

  Fly   211 GRAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGR------VAALVSSCFLA 269
            .....:|..::..:||........||:|.||...|.|..|:.||..||      ...||..|.
Human   191 PVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCG-- 253

  Fly   270 LVGSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLA--------- 325
             ||..|...||.....   |||:|.........||::.||...|..|..||   ||
Human   254 -VGGAAAGSSTGVMAL---RFLLGFLLAGVDLGVYLMRLELCDPTQRLRVA---LAGELVGVGGH 311

  Fly   326 -LFYSPFTMVMPWIALSAGNWRRFSSFTSLPIVLAMFSFC--LLPESARWLVSVGEIDKALEILK 387
             ||..        :||.:.:||......:.|.:|.:|...  |..||||||:...:|::|..:|:
Human   312 FLFLG--------LALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLR 368

  Fly   388 NVIEVNKK------QVSKEILDLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMS 446
            .:.|.|:.      :.::|.|...|.:|           .....|.|....:..|.    .||.:
Human   369 ILAERNRPHGQMLGEEAQEALQDLENTC-----------PLPATSSFSFASLLNYR----NIWKN 418

  Fly   447 ISLVYDGHVRAASVL----------DSENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYT 501
            :.::...:..|.::.          ...:.:|...:|..|.....:.:.:|:||.|||.......
Human   419 LLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSM 483

  Fly   502 SLSGVFSLLGASF---------------------QNRANMRMSALAGRFFSNICYNIGLQWAAEI 545
            :|:|:.||:....                     .|.|.:...::.|.|.|.....:....|||:
Human   484 TLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEV 548

  Fly   546 LPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFLPETLNHELP 610
            :||.||.:|:..|..:|.:..|..|..............:||.|..:...|..:.||||....||
Human   549 IPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLP 613

  Fly   611 ETLSDGAQFGKNQRIWHMPCCGPGSRKSH 639
            |.|.|| :..:...:...|   |.:|..|
Human   614 EVLRDG-ELCRRPSLLRQP---PPTRCDH 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	130/575 (23%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	99/425 (23%)
SLC22A17	NP_065105.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153318
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940