DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and slc22a15.1

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	XP_031751719.1	Gene:	slc22a15.1 / 448510	XenbaseID:	XB-GENE-959503	Length:	560	Species:	Xenopus tropicalis

Alignment Length:	558	Identity:	131/558 - (23%)
Similarity:	249/558 - (44%)	Gaps:	76/558 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 IDFDDLLPMIGQFGRFQIRL-FLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRK 157
            ::.:..|.::|:.|.:||.| ||..:.....:|...:....:..|||  |.::.:.|.......|
Frog    27 MEVEGALKLVGEMGIYQIYLSFLLAVLLQLYSATEAIIITILGATPP--YHWMNDSLTANGSRGK 89

  Fly   158 ELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAFESATMEFG 222
            :.......:|.:... :::.|:|.|     .|.:               |...|.|:|
Frog    90 QYGSQLPAEGEHGHV-VFDGNFTSI-----VSEW---------------FLVGGAAYE------- 126

  Fly   223 WLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFTFAI 287
                    .:.:..::|.|.::|.:::|..:|..||....|:...|.:|.::..:::..|..|.:
Frog   127 --------VSVSSSVYFGGVLIGVISFGQLSDRFGRKPVYVTGLALEVVFAVMNALTPIFPLFLL 183

  Fly   288 SRFLVGASYDTCFTMVYILVLEYVGPKYRTL---VANLSLALFYSPFTMVMPWIALSAGNWRRFS 349
            :|||||........:.::|:.|.:|..|...   :.:|..|:..:.|.::..:|.    :||..:
Frog   184 TRFLVGVMNGGMSLVAFVLLNECIGASYWAAAGSLGSLCFAVGIAQFALIGYFIR----SWRLLA 244

  Fly   350 SFTSL--PIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASCTQF 412
            ...::  ..|||: |.| :|||.|||.:.|.:.:|.|.|.::...|:::|:         |.|..
Frog   245 LLVNVQGAAVLAL-SLC-IPESPRWLHAQGRLREAQESLLSLGRRNRRKVT---------SFTLC 298

  Fly   413 YKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIFLFFTIACATE 477
            .:::.......:|:|:....:.:..::|:.:|...||||.|...::..|..: |:|...::...|
Frog   299 PRQKDSAHSANILTIYSNAILRQRTLIMMWVWFVCSLVYYGLTLSSGDLGGD-IYLNLALSGLAE 362

  Fly   478 LPGNILVILTLD--RAGRRWCSFFYTSLSGVFSLL--------GASFQNRANMRMSALAGRFFSN 532
            ||...|.:..::  |.|||.....:..:.|...||        |:...:..|.:..:|.|:...:
Frog   363 LPAYPLCMYLINHKRVGRRGSLAGFLCVGGGACLLIMLVPGKTGSGPLSVLNSQTLSLLGKLNIS 427

  Fly   533 ICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLL 597
            ..:||...:::|:.||.||..|:........:..:::|.:..|.....:...||.||.|:..|||
Frog   428 AAFNIVYIYSSELYPTCVRNLGMGVCSMFSRIGGIIAPFIPALRFAHWALPFIVFGAAGVSAGLL 492

  Fly   598 ALFLPETLNHELPETLSD--GAQFGK----NQRIWHMP 629
            :|.|||||:..|||||:|  ||.:.:    .:.:.|.|
Frog   493 SLLLPETLSAPLPETLADLRGAPYRRLEPDGEAMLHRP 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	122/523 (23%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	92/385 (24%)
slc22a15.1	XP_031751719.1	MFS	90..497	CDD:421695	101/458 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920