DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and CG6356

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	131/586 - (22%)
Similarity:	240/586 - (40%)	Gaps:	80/586 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TSLPRRSWETDDYIDFDDL----LPMIGQFGRFQIRLFLFMIP------FCFITAFVYLGQIFMC 135
            |..|.::.|........||    |.::|..|.|...:|...:.      | .::::..||.:
  Fly     5 TENPEKNRELISEESMKDLLTKQLEVVGSGGAFVWAIFFLCVTPNILNGF-HVSSYTLLGHL--- 65

  Fly   136 LTPPKYYCYVPELLHTP-VELRKELSIPKEKDGSYSRCRMYNTNY---TKIHF--AENPSAYINT 194
              |...:|.:|||..|. ...:|...:.|..|.  ..|.:::.||   .|:.:  |.|.:.::..
  Fly    66 --PDDQWCGIPELQDTNWTHAQKREIVAKGLDS--GGCTVWDWNYGHLAKMSYEAALNYTGHLTQ 126

  Fly   195 SLP--TIPCK-KGYVFEQEGRAFESATMEFGW--LCDDDKYATYAQIIFFLGSILGGLAYGHFAD 254
            ..|  .:.|: ||    |...|....|....|  .||.....|.||:...||...|..::|..||
  Fly   127 ISPPAEVSCRVKG----QHEFAHPETTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILAD 187

  Fly   255 HCGRVAALVSSCFLALVGSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLV 319
            ..||.::........:|||...:.|..:..|...||.:||:....|...:.:::|.:..|:|:.:
  Fly   188 KFGRKSSFTLGAAFFIVGSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWM 252

  Fly   320 ANLSLALFYSPFTMVMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALE 384
             :::.:..|....:::..:......||......::|.:|.:.:..|:.||.|||::....|:..:
  Fly   253 -SIAFSASYPVGMIILAIVGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYK 316

  Fly   385 ILKNVIEVNKKQVSKEILDLFEASCTQFYKEELDGRDF----------TVLSIFKRKRMARYMIL 439
            ||..  :.:..|:...:....:.:..:...|..:|..|          :::.::...::.|.:..
  Fly   317 ILFR--QPSHYQIQPAVAAPSQVASDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFA 379

  Fly   440 MILIWMSISLVYDGHVRAASVLDSENI----FLFFTIACATELPGNILVILTLDRAGRRWCSFFY 500
            ...::...||.|  :|.|   |::.|:    :|:.......::|..::.::.|...|||..:.|.
  Fly   380 SYFMFCVTSLSY--YVTA---LNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFL 439

  Fly   501 TSLSGVFSLLGASFQNRANMRMSALA--GRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGF 563
            ...:||..||..:....:...:.|.|  |||..:..|::...:.||:.||.:|...:....|...
  Fly   440 FLWTGVSLLLVLAVPAGSTTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAH 504

  Fly   564 VAMLMSPPVVYLSKKSLSSTLIVLGALG------------IFGGLLALFLPETLNHELPETLSDG 616
            |..:.:|.||           .||||||            :..|||.|.||||...:|.:.:...
  Fly   505 VGSISAPYVV-----------DVLGALGWYIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVESS 558

  Fly   617 A 617
            |
  Fly   559 A 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	124/552 (22%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	87/398 (22%)
CG6356	NP_651240.1	MFS	167..544	CDD:119392	86/395 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458484
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	6.990