DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Orct

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	163/542 - (30%)
Similarity:	267/542 - (49%)	Gaps:	37/542 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRK--- 157
            :||::..:|:||.:|.|::..:.....:.||..|..:|: |..|.:.|.:|....:..||..
  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFL-LAKPDFRCALPYENGSIYELSPHLW 66

  Fly   158 ELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLP-----TIPCKKGYVFEQEGRAFESA 217
            .||.|:.:     ||..|:.:||:        .|:|.|:|     |..| ..||::: .:...||
  Fly    67 NLSYPENE-----RCSYYDVDYTE--------EYLNGSIPRSSNETKTC-SSYVYDR-SKYLNSA 116

  Fly   218 TMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDF 282
            ..|:..:|.....:..:..:|.||.:||.|.:|..:|..||.....:|..|.|:..:..:::.::
  Fly   117 VTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEY 181

  Fly   283 FTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWRR 347
            |::.|||.:|||:....|.:.|::.||.||..|| |.|.:::.:|:|...|:....|....:||.
  Fly   182 FSYTISRMIVGATTSGVFLVAYVIALEMVGSSYR-LFAGVAMQMFFSVGFMLTAGFAYFIHDWRW 245

  Fly   348 FSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILD-LFEASCTQ 411
            .....:||.:|.:..:.::|||||||:..|..|:|..|::...:.||.:|..||.: |.:....:
  Fly   246 LQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEK 310

  Fly   412 FYKEELDGRD--FTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIFLFFTIAC 474
            ..::|:....  .||..:.:...:.|..:|:...|...|.||.|.....:.|.. |..:.|.|:.
  Fly   311 KKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGG-NQLVNFMISG 374

  Fly   475 ATELPGNILVILTLDRAGRR--WCSFFYTSLSGVFSLLGASF-QNRANMRMSALA--GRFFSNIC 534
            |.|:||..|::.||:|.|||  .|.   |.:....|||...| .:..|..:.|.|  |:......
  Fly   375 AVEIPGYTLLLFTLNRWGRRSILCG---TMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSS 436

  Fly   535 YNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLAL 599
            |.....::||..|||||..|:.....:..|..:::|.:..|.:......||:.|||.:..|||:|
  Fly   437 YGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSL 501

  Fly   600 FLPETLNHELPETLSDGAQFGK 621
            .||||||..:|||:.||..|||
  Fly   502 LLPETLNKPMPETIEDGENFGK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	154/523 (29%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	112/378 (30%)
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	154/523 (29%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	105/360 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458412
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.890