DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and CG6231

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	611	Identity:	192/611 - (31%)
Similarity:	295/611 - (48%)	Gaps:	100/611 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 IDFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFV---YLGQIFMCLTPPKYYCYVPELLHTPVEL 155
            :|||.:|...|.|.|:|   |:.:..|.||...|   |..|..:... |.::||..:|:
  Fly     1 MDFDQILAKCGDFNRYQ---FMILALFGFINIIVSMHYFTQTVISFV-PDHWCYHDKLV------ 55

  Fly   156 RKELSIPKEKDGSYSRCRMYNTNYTKIH--FA--ENPSAY-------INTSLPTIPCKK---GYV 206
                                |..|.:|.  :|  ||||..       .|.::.:..|:|   .|.
  Fly    56 --------------------NMTYKEIGEIYAQFENPSCTRLDDINGHNVTVSSKACEKWIYNYD 100

  Fly   207 FEQEGRAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALV 271
            |     .:.|...|..|:||....|...|.:||:||::|.|.||..:|..|||.||:.|.|....
  Fly   101 F-----GYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFA 160

  Fly   272 GSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMP 336
            |..:|..:....||.:.||:.|.:.||.|.::||:||||:.|..|||..|:::.|||....:..|
  Fly   161 GDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTP 225

  Fly   337 WIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEI 401
            |:|:..|:|:.:.:.|||||:|.:..:.::.|||:|||:..:||.|:..||.|.:.|..:||:..
  Fly   226 WLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQAD 290

  Fly   402 LDLFEASCTQFYKEELDGRD---FTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDS 463
            .|.|...| |...|.|.|.|   .|:|.:|:..||.:..:::....|.|:|.||.        .|
  Fly   291 FDEFRRHC-QMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDA--------VS 346

  Fly   464 ENI-------FLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSL---LGASFQ--- 515
            .|:       |:.|:::....||.::|::|..||.||:..:.....:.|:|:.   :..::|
  Fly   347 RNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHN 411

  Fly   516 -NRANMRMSALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKS 579
             |...:....:|.||...|.|..|.|:|.|::||.||.||||.:|..||.|..::|.:::|....
  Fly   412 HNAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTFF 476

  Fly   580 LSSTLIVLGALGIFGGLLALFLPETLNHELPETLSDGAQFGKNQRIWHMPCCGPGSRKSHPRHNW 644
            .::..|:||.|...|..:.|.||||||..||.|:.:|..|||.:|::..||.          ||.
  Fly   477 KAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGERMFDFPCL----------HNK 531

  Fly   645 HQGSSLRTLSKDEFRSSKMYRKTKYR 670
            |.         ||...|::   .||:
  Fly   532 HD---------DEESESEL---EKYK 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	172/541 (32%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	131/387 (34%)
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	172/541 (32%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	129/382 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471409
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	8.010