DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and CG16727

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_650818.1	Gene:	CG16727 / 42338	FlyBaseID:	FBgn0038719	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	590	Identity:	187/590 - (31%)
Similarity:	301/590 - (51%)	Gaps:	67/590 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 IDFDDLLPMIGQFGRFQIRLFLFMIPFCF---ITAFVYLGQIFMCLTPPKYYCYVPELLHT-PVE 154
            :|||.:|...|.|||||   |:.:|.:.:   :::..|..|..:..| |:::|...:|:.. ..|
  Fly     1 MDFDRVLEKCGNFGRFQ---FVILILYGYTNILSSLHYFSQTLITFT-PEHWCSHDDLMGLGAAE 61

  Fly   155 LRKELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYIN-TSLPTIPCKKGYVFEQEGRAFESAT 218
            ||...|     :.|:..|.:.             |..|| |.:.:....:.::||:| ..:||.|
  Fly    62 LRSIYS-----NVSHPSCTLL-------------SEVINGTGVASEESCQDWIFERE-NGYESLT 107

  Fly   219 MEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFF 283
            .|..|:||........|..|||||::|.:::|..:||.||:.|::.:......|...||......
  Fly   108 TELKWVCDKSHQPAVGQSFFFLGSVVGTISFGFLSDHIGRLPAMLMAALSGATGDFITSFVHTLP 172

  Fly   284 TFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWRRF 348
            .||.|||:.|.|.||.:.::||||.||:.||.||...|:.||:||....|..||||:..|||||:
  Fly   173 WFAFSRFVSGLSTDTMYYLMYILVFEYLSPKRRTFGLNIILAVFYCFGLMTSPWIAMWIGNWRRY 237

  Fly   349 SSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASCTQFY 413
            ....|||.:..:....|:.|||:||::..:.|:|:..||.|.:.|.:||...:.|.|    .:.|
  Fly   238 LWLASLPALGVLIYPLLICESAQWLLTKKKYDEAVACLKKVAKFNGRQVEDSVFDEF----VKHY 298

  Fly   414 KE------ELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIFLFFTI 472
            :|      :|:.:..|.|.:||..|:.|:...:::..:.|:|.||...|....|.| :.|..|::
  Fly   299 REKMNEESKLNKQMDTFLGMFKTPRLRRFTTTLLVKSVIITLSYDVINRNMEGLGS-SPFKLFSL 362

  Fly   473 ACATELPGNILVILTLDRAGRRWCS-------FFYTSLSG-VFSLLGASFQNRANMRMSALAGRF 529
            ..:..||....::|..::.||:..:       ...|:::| :.::|..| :|...:.:....|||
  Fly   363 TSSVYLPAGFTILLLQNKIGRKGMACGALLVGAIITAVTGFLIAVLDPS-ENAVLLALMVGLGRF 426

  Fly   530 FSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSK--KSLSSTLIVLGALGI 592
            .:.:.|:..:|:||||:||.||.|.|:.||.:|..:..::..|:||::  |.|.|  |.:..|..
  Fly   427 GTTVSYDAEIQYAAEIIPTSVRGQAVSNIHVVGLASSSLAFYVIYLAQYYKPLPS--IFISVLMF 489

  Fly   593 FGGLLALFLPETLNHELPETLSDGAQFGKNQRIWHMPCCGPGSRKSHPRHNWHQGSSLRTLSKDE 657
            .|.||.|.|||||:.:|||||:||.:|..|:...:.||.       |.|.        .:|::.|
  Fly   490 LGALLCLTLPETLHKKLPETLADGERFAMNESCLYFPCL-------HKRR--------ESLTEHE 539

  Fly   658 FRSSK 662
            .|.|:
  Fly   540 DRKSE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	168/528 (32%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	127/386 (33%)
CG16727	NP_650818.1	2A0119	11..509	CDD:273328	168/528 (32%)
CG16727	NP_650818.1	MFS	125..499	CDD:119392	126/381 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471410
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	8.010