DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and CG8925

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_650526.1	Gene:	CG8925 / 41963	FlyBaseID:	FBgn0038404	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	128/537 - (23%)
Similarity:	217/537 - (40%)	Gaps:	102/537 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 CFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKELSIPKEKDGSYSR--CRMYNTNYTKIH 183
            |....|||:.||    .|..::|..||.|       .::|:.:.::.|.|.  |.:.:.:||::.
  Fly   175 CTFHIFVYVFQI----APKDFWCARPENL-------MQMSVSEWRNISQSSNGCLLLDVDYTQVT 228

  Fly   184 FAENPSAYIN-----TSLPTIPCKKGYVFEQEGRAFESATMEFGWLCDDDKYATYAQIIFFLGSI 243
            :..|  ..||     |.|....|......:.:|.| ::...||..:|..| ..:..:..|.:|:.
  Fly   229 YENN--QLINWPENATDLGYRQCWHFEFSDVDGSA-KTLVQEFDLVCGRD-ILSLVETCFLVGAA 289

  Fly   244 LGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVL 308
            .|.:..|..:|..||...|::...:..|.....:.||....|...|.::|.:..|...:.::||:
  Fly   290 AGAVLSGWISDRFGRRHTLMAFVTIQSVFGGILAFSTSVAMFMSLRVIIGFASMTVTVVSFVLVV 354

  Fly   309 EYVGPKYRTLVANLSL---ALFYSPFTMVMPWIALSAG------NWRRFSSFTSLPIVLAMFSFC 364
            |.|..|:||::..|::   |:.|          .||||      :||......|.|.::.:..:.
  Fly   355 ELVSGKWRTVIGILNILPVAISY----------VLSAGLAYLIRDWRHLQLAISWPWLIMLSIWF 409

  Fly   365 LLPESARWLVSVGEIDKALEILKNVIEVNKKQVS-----KEILDLFEASCTQFYKE--------- 415
            .||||.|||::.|.:|:...:::....:|....|     ::.|:.......|...|
  Fly   410 WLPESPRWLLAQGRLDELCGLIERAARMNGTSASLPSNYRKTLEAAVPRAVQSPPEATTSVESKA 474

  Fly   416 -ELDGRDFT-------VLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIFLFFTI 472
             |.|..|.:       :|.:|..|.. |...|.::||:::.::|.|.....|.|.. ||::...:
  Fly   475 VEADAPDPSASGHVNPLLVVFSAKYW-RTTCLTLVIWLTLIIIYFGLTLHLSNLGG-NIYINSAV 537

  Fly   473 ACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASFQNRANMRMSALAGRFFSNICYNI 537
            |...|.....:.||.:.:.|.|      .||.|...|.|          :..||....||....|
  Fly   538 AGTVEAISICISILVVLKVGIR------RSLIGYMLLPG----------LCCLATNLVSNQTGVI 586

  Fly   538 GLQWAAEIL----------------PTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIV 586
            .|...|:.|                ||:||..||...:....:|:::.|   :|.|......|:.
  Fly   587 ALATIAKCLIGANNAIIPTYTAMQYPTIVRNFGVGMGNLASGIALILVP---FLWKLEHIDPLLP 648

  Fly   587 LGALGIFG--GLLALFL 601
            |..:|:.|  |.:|:.|
  Fly   649 LNVMGVCGLIGAVAISL 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	128/537 (24%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	99/420 (24%)
CG8925	NP_650526.1	MFS	277..667	CDD:119392	99/420 (24%)
CG8925	NP_650526.1	MFS_1	277..635	CDD:284993	89/385 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	6.060