DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10486 and slc22a4

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	546	Identity:	138/546 - (25%)
Similarity:	237/546 - (43%)	Gaps:	52/546 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKEL 159
            |:||:...:|.:|.||:.:||.:........||.|..:|:..| |.:.|.:||.::.. .:.::.
Zfish     3 DYDDITSFLGTWGPFQLTVFLALAISILPNGFVGLYIVFVGDT-PAHECLIPEQINIS-SVWRDA 65

  Fly   160 SIPKE-KDGSYSR--CRMYN---------TNYTKIHFAENPSAYINTS-LPTIPCKKGYVFEQEG 211
            :||.: :||...|  |..|.         .|||       |:..:|.| :.|.||..|:.:.||
Zfish    66 AIPTQMQDGVLKRSSCSRYRLDTLRQLSMLNYT-------PNVEVNLSQIETEPCVDGWSYSQE- 122

  Fly   212 RAFESATMEFGW--LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSL 274
              |..:|:...|  :|:.:........|:|.|.::|....|..:|..||...|.:...|..:..|
Zfish   123 --FYQSTIVTEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMALQTITIL 185

  Fly   275 ATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIA 339
            ....|..:..|:...|.||.|..:.:.:.|:|..|.:.|..|.|..:|.:.:......|..|..|
Zfish   186 IQMFSPSWEVFSAIYFFVGFSGFSNYVVAYVLGSEILSPASRVLFGSLGVFMGSGIGQMFFPLAA 250

  Fly   340 LSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEIL-- 402
            ....:||......:|..:|....:..:|||.|||:|.|...:|..:|:...|.|:....:.|.
Zfish   251 YFIRSWRWLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRVTAPEVIFSS 315

  Fly   403 -DLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENI 466
             ::.||:..:..|.       ::|.|.........:::..|:||.|::.|     .|.:|::.|:
Zfish   316 SEIEEAAKKRIQKH-------SILDILSNCNAVSTILICSLLWMVITMSY-----YALILNTTNL 368

  Fly   467 ----FLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSG----VFSLLGASFQNRANMRMS 523
                :|.|.::...|:|..|:..|.|....||.|......|.|    :..|:....|..|.  ..
Zfish   369 HGNPYLNFFLSAVVEVPAYIIAALLLRFCSRRICQASTLLLGGALIFIIQLIPTELQGLAT--AL 431

  Fly   524 ALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLG 588
            .:.|:......:.:.....:|:.|||||...:........:..::||.::||.........||:|
Zfish   432 EMLGKLCVTAAFCVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIYLGNYYRYIPYIVIG 496

  Fly   589 ALGIFGGLLALFLPETLNHELPETLS 614
            .|.:|.|:::|.|||:....||||::
Zfish   497 GLALFSGVMSLLLPESKGKVLPETIA 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	133/533 (25%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	90/381 (24%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	133/533 (25%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	90/379 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588477
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950