Protein Alignment CG10486 and SLC22A10

DIOPT Version :10

• Sequence 1: NP_647998.2
• Gene: CG10486 / 38664
• FlyBaseID: FBgn0035647
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_001034841.3
• Gene: SLC22A10 / 387775
• HGNCID: 18057
• Length: 541
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 147/577 - (25%)
• Similarity: 250/577 - (43%)
• Gaps: 93/577 - (16%)

  Fly    96 FDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTP-----------PKYYCYVPEL- 148
            |::||..:|..||||:...:|::|            ..|.|.|           |.:.|:|..|
Human     3 FEELLSQVGGLGRFQMLHLVFILP------------SLMLLIPHILLENFAAAIPGHRCWVHMLD 55

  Fly   149 -----------LHTPVELRKELSIPKEKDGSYSRCRMY-NTNYTKIHFAENPSAYINTSLPTIPC 201
                       |.....||  :|||.:.:....:||.: :..:..:|.  |.:.:..:...|.||
Human    56 NNTGSGNETGILSEDALLR--ISIPLDSNLRPEKCRRFVHPQWQLLHL--NGTIHSTSEADTEPC 116

  Fly   202 KKGYVFEQEGRAFESATMEFGW--LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVS 264
            ..|:|::|   ::..:|:...|  :||.....:..|.:...|.::||:..||.:|..|| ..::.
Human   117 VDGWVYDQ---SYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGR-RFILR 177

  Fly   265 SCFLAL-VGSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFY 328
            .|.|.| :.....:.:..|..:.:.|||.|.|.....:...:.:.|::.|..:.||..||....
Human   178 WCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGAL- 241

  Fly   329 SPFTMVMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLP----ESARWLVSVGEIDKALEILKNV 389
            |...:::..:|....:|:......|:|    .|.|.||.    ||||||:...::|:.|:.|:.|
Human   242 SIGQIILGGLAYVFRDWQTLHVVASVP----FFVFFLLSRWLVESARWLIITNKLDEGLKALRKV 302

  Fly   390 IEVNKKQVSKEILDLFEASCTQFYKEELDGRD--FTVLSIFKRKRMARYMILMILIWMSISLVYD 452
            ...|..:.::|.|::.....|.  :||||...  .||..:|:...|.:.:.:::.:..:.::.:.
Human   303 ARTNGIKNAEETLNIEVVRSTM--QEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFY 365

  Fly   453 G------HVRAASVLDSENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLG 511
            |      ||       ..||||...:..|..|....|.:|||:..|||.....:..|.|: |:|.
Human   366 GTMVNLQHV-------GSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGL-SILA 422

  Fly   512 ASF--QNRANMRMSALAGRFFSNICYNIGLQWAA---------EILPTVVRAQGVAFIHTMGFVA 565
            .:|  :....:|: |||       |..||...|.         |::|||:||:......|...:.
Human   423 NTFVPKEMQTLRV-ALA-------CLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIG 479

  Fly   566 MLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFLPETLNHELPETLSDGAQFGKN 622
            ..::|.::.|:....:...|:.|...|.|||:...||||.|..||:|:.|.....||
Human   480 AALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKN 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	140/557 (25%)
SLC22A10	NP_001034841.3	MFS_OAT	109..516	CDD:340932	109/433 (25%)