DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and SLC22A10

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001034841.3	Gene:	SLC22A10 / 387775	HGNCID:	18057	Length:	541	Species:	Homo sapiens

Alignment Length:	577	Identity:	147/577 - (25%)
Similarity:	250/577 - (43%)	Gaps:	93/577 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTP-----------PKYYCYVPEL- 148
            |::||..:|..||||:...:|::|            ..|.|.|           |.:.|:|..|
Human     3 FEELLSQVGGLGRFQMLHLVFILP------------SLMLLIPHILLENFAAAIPGHRCWVHMLD 55

  Fly   149 -----------LHTPVELRKELSIPKEKDGSYSRCRMY-NTNYTKIHFAENPSAYINTSLPTIPC 201
                       |.....||  :|||.:.:....:||.: :..:..:|.  |.:.:..:...|.||
Human    56 NNTGSGNETGILSEDALLR--ISIPLDSNLRPEKCRRFVHPQWQLLHL--NGTIHSTSEADTEPC 116

  Fly   202 KKGYVFEQEGRAFESATMEFGW--LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVS 264
            ..|:|::|   ::..:|:...|  :||.....:..|.:...|.::||:..||.:|..|| ..::.
Human   117 VDGWVYDQ---SYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGR-RFILR 177

  Fly   265 SCFLAL-VGSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFY 328
            .|.|.| :.....:.:..|..:.:.|||.|.|.....:...:.:.|::.|..:.||..||....
Human   178 WCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGAL- 241

  Fly   329 SPFTMVMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLP----ESARWLVSVGEIDKALEILKNV 389
            |...:::..:|....:|:......|:|    .|.|.||.    ||||||:...::|:.|:.|:.|
Human   242 SIGQIILGGLAYVFRDWQTLHVVASVP----FFVFFLLSRWLVESARWLIITNKLDEGLKALRKV 302

  Fly   390 IEVNKKQVSKEILDLFEASCTQFYKEELDGRD--FTVLSIFKRKRMARYMILMILIWMSISLVYD 452
            ...|..:.::|.|::.....|.  :||||...  .||..:|:...|.:.:.:::.:..:.::.:.
Human   303 ARTNGIKNAEETLNIEVVRSTM--QEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFY 365

  Fly   453 G------HVRAASVLDSENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLG 511
            |      ||       ..||||...:..|..|....|.:|||:..|||.....:..|.|: |:|.
Human   366 GTMVNLQHV-------GSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGL-SILA 422

  Fly   512 ASF--QNRANMRMSALAGRFFSNICYNIGLQWAA---------EILPTVVRAQGVAFIHTMGFVA 565
            .:|  :....:|: |||       |..||...|.         |::|||:||:......|...:.
Human   423 NTFVPKEMQTLRV-ALA-------CLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIG 479

  Fly   566 MLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFLPETLNHELPETLSDGAQFGKN 622
            ..::|.::.|:....:...|:.|...|.|||:...||||.|..||:|:.|.....||
Human   480 AALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKN 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	140/557 (25%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	99/394 (25%)
SLC22A10	NP_001034841.3	2A0119	11..526	CDD:273328	140/557 (25%)
SLC22A10	NP_001034841.3	MFS	143..516	CDD:119392	99/396 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153703
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940