DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	XP_038941497.1	Gene:	Slc22a12 / 365398	RGDID:	621628	Length:	578	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	155/584 - (26%)
Similarity:	243/584 - (41%)	Gaps:	96/584 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQ-IRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHT------PV 153
            |.:||..:|..|||| ::....:.|..::|....|......:  |.:.|:||.|.::      |.
  Rat     3 FPELLDRVGGRGRFQLLQAVALVTPILWVTTQNMLENFSAAV--PHHRCWVPLLDNSTSQASIPG 65

  Fly   154 ELRKE----LSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAF 214
            :..::    :|||...|....:|..:.....:: ...|.:|...:...|.||:.|:|::..  .|
  Rat    66 DFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQL-IESNTTATNWSDADTEPCEDGWVYDHS--TF 127

  Fly   215 ESATMEFGW--LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALV-GSLAT 276
            .| |:...|  :||.......||.||..|.::|....||.:|..||...|..|..|..| |::|.
  Rat   128 RS-TIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTIAA 191

  Fly   277 SMSTDFFTFAISRFLV-----GASYDTCFTMVYILVLEYVG----PKYRTLVANLSLALFYSPFT 332
            .|.| |..:.:.||||     |...:|....::.:||...|    |:   |..:|.||
  Rat   192 LMPT-FPLYCLFRFLVASAVAGVMMNTASLCMFPVVLGREGYMQDPE---LTPSLLLA------- 245

  Fly   333 MVMPWIALSAG--------------------------NWRRFSSFTSLPIVLAMFSFCLLPESAR 371
             ||.|.:..||                          :||......|.|..|.......||||||
  Rat   246 -VMEWTSAQAGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESAR 309

  Fly   372 WLVSVGEIDKALEILKNVIEVNKKQVSKEIL--DLFEASCTQFYKEELDGRD--FTVLSIFKRKR 432
            ||::||.:|::|..|:.|..||:::...:.|  ::..::    .:||.:|..  ..:.::.....
  Rat   310 WLITVGRLDQSLRELQRVAAVNRRKAEADTLTVEVLRSA----MQEEPNGNQAGARLGTLLHTPG 370

  Fly   433 MARYMILMILIWMSISLVYDGHVRAASVLDSENIFLFFTIACATELPGNILVILTLDRAGRRWCS 497
            :.....:.:|.|.:....:.|.......|.| ||||...:....:||..:..:|.|.|.|||.|.
  Rat   371 LRLRTFISMLCWFAFGFTFYGLALDLQALGS-NIFLLQALIGIVDLPVKMGSLLLLSRLGRRLCQ 434

  Fly   498 FFYTSLSGVFSLLGASFQNRANMRMSALA-------GRFFSNICYNIGLQWAAEILPTVVRAQGV 555
            .....|.|:..|..........:..|:||       |..|:  |..|   :::|:.|||:|...|
  Rat   435 ASSLVLPGLCILANILVPREMGILRSSLAVLGLGSLGAAFT--CVTI---FSSELFPTVIRMTAV 494

  Fly   556 AFIHTMGFVA----MLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFLPETLNHELPETLSD 615
            .    :|.||    .::.|.|..|........|:|.|.:.:..||.||.||||.|..||:|:.|
  Rat   495 G----LGQVAARGGAMLGPLVRLLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQD 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	150/571 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	111/421 (26%)
Slc22a12	XP_038941497.1	MFS_OAT	109..541	CDD:340932	122/460 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346845
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950