DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and CG4630

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	593	Identity:	164/593 - (27%)
Similarity:	278/593 - (46%)	Gaps:	88/593 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 IDFDDLLPMIGQFGRFQIRLFLFM-IPFCFITAFVYLGQIFMCLTPPKYYCYVPE---LLHTPVE 154
            :||||:|..||:|||||.|.:|.: :|..|..| ..|..:|.. ..|.|.|||||   |:.....
  Fly    13 LDFDDILVEIGEFGRFQRRNYLLICLPVLFAAA-NSLSYVFTA-GSPTYRCYVPECDKLVDAEYG 75

  Fly   155 LR-KELSIPKEKDGSYSR--------CRMYNTNYTKIHFAENP-SAY-------INTSLPTIPCK 202
            .. ..:::|    ||:|:        |..:..|...:..:.:| ||:       .|.:..|..|.
  Fly    76 ANWVSIAVP----GSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCN 136

  Fly   203 KGYVFEQEGRAFESATMEFGWLCDDDKY-ATYAQIIFFLGSILGGLAYGHFADHCGRV-AALVSS 265
            : :|:   |.:..:...::|..|.::.: ..:...|.|.|.::|....|:.||..||. ..|...
  Fly   137 Q-FVY---GSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCI 197

  Fly   266 CFLALVGSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSP 330
            .|:||.| :|.::|.|:.:|.....|........:.:.:|:.:|.|||:.|.: :::.|..||:.
  Fly   198 VFMALTG-VAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREM-SSIVLNYFYAV 260

  Fly   331 FTMVMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKK 395
            ...:: .:::...:||:.....|:|.::.:..|.|:|||.|||::....::|..|::...:||::
  Fly   261 GEALL-GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRR 324

  Fly   396 QVSKEILDLFEASCTQFYKEELD---GRDFTV-------------LSIFKRKR----MARYMILM 440
            .:|.|::       ..|.::|||   |::..|             |::.:..|    |.||.||
  Fly   325 DISVELM-------ASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAIL- 381

  Fly   441 ILIWMSISLVYDG-HVRAASVLDSENIFLFFTIACATELPGNILVILTLDRAGRR--------WC 496
            :|||...::||.| .:.|.|:  |.|.:|.|.:.|..|:||..|..|.|.|.|||        .|
  Fly   382 LLIWAVNAIVYYGLSLNATSL--SGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLC 444

  Fly   497 SF------FYTSLSGVFSLLGASFQNR-----ANMRMSA--LAGRFFSNICYNIGLQWAAEILPT 548
            |.      |.|...|.:.......::|     ||..:..  |.|:......:.:...:.||::||
  Fly   445 SITCVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPT 509

  Fly   549 VVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFLPETLNHELPETL 613
            |:|:.||..:.|......:::|.|..|:.......|::.|.|.:..|||:|.||||.|.:||:|:
  Fly   510 VIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTV 574

  Fly   614 SDGAQFGK 621
            .:....||
  Fly   575 EEAIALGK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	155/572 (27%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	111/413 (27%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	155/572 (27%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	102/387 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458521
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.890