DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Slc22a22

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001013969.1	Gene:	Slc22a22 / 299944	RGDID:	1304605	Length:	555	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	134/547 - (24%)
Similarity:	233/547 - (42%)	Gaps:	47/547 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHT--------- 151
            ||::|..:|..|||||.:.:.:.....:::...:.:.|.... |.::|.| .||.|
  Rat     3 FDEILHHVGDRGRFQIWMIVVLNILSMVSSLHDVIENFTAAI-PAHHCSV-NLLDTSRSEISMAM 65

  Fly   152 --PVELRKELSIPKEKDGSYSRCRMYNTNYTKIHFAE-NPSAYINTSLPTIPCKKGYVFEQEGRA 213
              ..|...::|||...:....:||.:  .:.:..|.: |.|...:|.|.|.||..|:.::..  .
  Rat    66 NLTTEAMMKVSIPMGPNQKPEQCRRF--RHPQWQFIDSNISTSNSTELETEPCLDGWTYDHS--V 126

  Fly   214 FESATM-EFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLAT- 276
            |.|..: |:..:||...:..|||.....|..:.....|..:|..|| ..|:..|.|| .|.|.|
  Rat   127 FTSTIVTEWDLVCDFQSFKYYAQATSLAGHFVAAPFCGIISDRFGR-KPLLMYCSLA-YGILGTC 189

  Fly   277 -SMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIAL 340
             :...:|..:.:.|||..||..|......|||||....::...|..|| .||.|.....:..:|.
  Rat   190 CAFVPNFSLYCVLRFLSSASASTVGMNCLILVLEETSVQWHATVIVLS-GLFSSTGLAGLGGLAY 253

  Fly   341 SAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVN-KKQVSKEIL-- 402
            ...:|......::||..:....||.:|||||||:..|:.|:||:.|:.:..:| ||.:::.:.
  Rat   254 VLSDWHLIQLTSALPYFIFFILFCWVPESARWLMITGKTDQALKELQRIASINGKKDIAQNLTTE 318

  Fly   403 DL----FEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDS 463
            ||    .|..|:..  :....:|..:..:.::..:....:|...::....|:.|.|:.      .
  Rat   319 DLRSKVKEDVCSTV--KHFSIKDIIINPMIRKIVLCYSSVLFAELFSIFGLLLDVHML------G 375

  Fly   464 ENIFLFFTIACATELPGNILVILTLDRAGRR-WCSFFYTSLSGVFSLLGASFQNRANMRMSALAG 527
            :|||:...:....::|...|....|....|| ..:|...:..|..::  ..|.:. :|.:..||.
  Rat   376 KNIFVTQILLGVIDIPSKSLTYFILRNVRRRPLIAFLLFATGGCITI--TMFLSE-DMYVLRLAI 437

  Fly   528 RFFSNICY----NIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLG 588
            ......|:    :|...:..|:.|..:|:.......::..:|.::|...:...|..:...:|..|
  Rat   438 FILGKGCFAAFISINTAYCNELSPVPLRSTLNGIYISVARLASVLSALTLVTRKYFVLLPMIFCG 502

  Fly   589 ALGIFGGLLALFLPETLNHELPETLSD 615
            .|.|...:...|||||.||.:.:|:.|
  Rat   503 VLPIVATINIYFLPETFNHPITDTIKD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	129/534 (24%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	90/384 (23%)
Slc22a22	NP_001013969.1	2A0119	11..526	CDD:273328	129/534 (24%)
Slc22a22	NP_001013969.1	MFS	127..516	CDD:119392	95/402 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347425
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940