DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	151/590 - (25%)
Similarity:	251/590 - (42%)	Gaps:	61/590 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DFDDLLPMIGQFGRFQIRLFLFMIPFCFI-TAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKE 158
            |:|::...:|::|.|| ||..|::....| ..|..:..:|:..| |::.|.||..::.....|..
  Rat     3 DYDEVTAFLGEWGPFQ-RLIFFLLSASIIPNGFNGMSIVFLAGT-PEHRCLVPHTVNLSSAWRNH 65

  Fly   159 LSIPKE-KDGSY--SRCRMYN----TNYTKIHFAENPSAYIN-TSLPTIPCKKGYVFEQEGRAFE 215
             |||.| |||..  ..||.|.    .|::.:..  .|...:: ..|....|..|:.:.::  .|.
  Rat    66 -SIPLETKDGRQVPQSCRRYRLATIANFSALGL--EPGRDVDLEQLEQENCLDGWEYNKD--VFL 125

  Fly   216 SATM-EFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMS 279
            |..: |:..:|.||..|.....:||:|.::|....|..:|..||...|..:..:....|.....|
  Rat   126 STIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQLFS 190

  Fly   280 TDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGN 344
            .:|..|.:...|||....:.:...::|..|.:....|.:.|.|.:.:||:...||:|..|....:
  Rat   191 VNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRD 255

  Fly   345 WRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASC 409
            ||......::|.||....:..:|||.|||:|.|.:.:|..|::...:.|.......|.|..|.
  Rat   256 WRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFDPSEL-- 318

  Fly   410 TQFYKEELDGR---DFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSEN----IF 467
                 ::|:.:   ...:..:.:.:.:....|:.|::|::||:.|.|     ..||:.|    |:
  Rat   319 -----QDLNSKKPQSHHIYDLVRTRNIRIITIMSIILWLTISVGYFG-----LSLDTPNLHGDIY 373

  Fly   468 LFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASFQNRANMRMSAL------- 525
            :...:..|.|:|..:|..|.|....||:      |:|... .||.|......:..|.|
  Rat   374 VNCFLLAAVEVPAYVLAWLLLQHLPRRY------SISAAL-FLGGSVLLFIQLVPSELFYLSTAL 431

  Fly   526 --AGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLG 588
              .|:|.....|::...:.||:.|||||..||....|...:..::||..|||.........|::|
  Rat   432 VMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMG 496

  Fly   589 ALGIFGGLLALFLPETLNHELPETLSDGAQFGKNQRIWHMPCCGPGSRKSHPRHNWHQGSSLRTL 653
            :|.|...:|.||.||:....||:|:....:. |..:.|.:        :|..|.....|.|...|
  Rat   497 SLTILTAILTLFFPESFGAPLPDTIDQMLRV-KGIKQWQI--------QSQTRTQKDGGESPTVL 552

  Fly   654 SKDEF 658
            ....|
  Rat   553 KSTAF 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	140/533 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	99/386 (26%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	140/533 (26%)
		MFS	123..510	CDD:119392	105/405 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347297
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850