DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Sv2c

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_113781.1	Gene:	Sv2c / 29643	RGDID:	619718	Length:	727	Species:	Rattus norvegicus

Alignment Length:	794	Identity:	155/794 - (19%)
Similarity:	248/794 - (31%)	Gaps:	332/794 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ANDEKGNAST----EDDDKPKKREHR-----DQGQQSKLKKIKYYIEPDKVDIGIQAGDSLEKVK 57
            |||::|::..    :::|:..:.|::     :||:.|            .|.:|...||..
  Rat    69 ANDDEGSSEATEGHDEEDEIYEGEYQGIPSTNQGKDS------------IVSVGQPKGDEY---- 117

  Fly    58 VTYVEPDDEESSHGFFWGKKKSETSLPRRSWETDDYIDFDDLLPMIGQFGRFQIRLFLFMIPFCF 122
                              |.:.|....||:.|.:....::.::...|. ||||..||
  Rat   118 ------------------KDRRELESERRADEEELAQQYELIIQECGH-GRFQWALF-------- 155

  Fly   123 ITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKELSIPKEKDGSYSRCRMYNTNYTKIHFAEN 187
               || ||...|.                              ||    ..::...:..
  Rat   156 ---FV-LGMALMA------------------------------DG----VEVFVVGFVL------ 176

  Fly   188 PSAYINTSLPTIPCKKGYVFEQEGRAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHF 252
            |||..:..:|                 .|.:   |||..          |.:||.::|...:|..
  Rat   177 PSAETDLCIP-----------------NSGS---GWLGS----------IVYLGMMVGAFFWGGL 211

  Fly   253 ADHCGRVAALVSSC-----FLALVGSLATSMSTDFFTFAISRFLVGASYDTCFT-MVYILVLEYV 311
            ||..||..:|: .|     |.|.:.|.............:|.|.:|.:..|.|: ...:|..|..
  Rat   212 ADKVGRKQSLL-ICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYFAEVLAREKR 275

  Fly   312 GPKYRTLVANLS-LALFY---SPFTMVMPWI-------ALSAG------NWRRFSSFTSLPIVLA 359
            |       .:|| |.:|:   ..:...|.|.       :.|.|      :||.|....:||.|.:
  Rat   276 G-------EHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSS 333

  Fly   360 MFSFCLLPESARWLVSVGEIDKALEILK--------------NVIEVNKKQVSKEILDLFEAS-- 408
            :.:...:|||.|:|:.||:.|:|..|||              .|..|||.:..|:|.:|.|..
  Rat   334 VVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESD 398

  Fly   409 -------CTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDG------------- 453
                   |....:.||.|...|.:..|... :....|.:.::|.::|..|.|
  Rat   399 TGTWYRRCFVRIRTELYGIWLTFMRCFNYP-VRENTIKLTIVWFTLSFGYYGLSVWFPDVIKHLQ 462

  Fly   454 -----------------------------H------------VRAASVLDSENIF---------- 467
                                         |            |:..||...:::|
  Rat   463 SDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGRFLGVKFKSVTFKDSVFKSCTFDDVTS 527

  Fly   468 ------------------------------------------------------LFFT--IACAT 476
                                                                  ::|.  :....
  Rat   528 VNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLA 592

  Fly   477 ELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGAS-----FQNRANMRMSALAGRFFSNICYN 536
            .|||||:..|.:||.||      .|.|.|...|.|.|     |....:|.:..|        |..
  Rat   593 VLPGNIVSALLMDRIGR------LTMLGGSMVLSGISCFFLWFGTSESMMIGML--------CLY 643

  Fly   537 IGLQWAA---------EILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGI 592
            .||..:|         |:.||..||.|..|::.:...|.::. .:::.|..|::..:.:|.|..:
  Rat   644 NGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLG-NLIFGSLVSITKAIPILLASTV 707

  Fly   593 F--GGLLALFLPET 604
            .  |||:.|.||:|
  Rat   708 LVCGGLVGLRLPDT 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	137/683 (20%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	112/552 (20%)
Sv2c	NP_113781.1	synapt_SV2	1..727	CDD:130366	155/794 (20%)
		Interaction with SYT1. /evidence=ECO:0000269\|PubMed:15866046	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..120		14/84 (17%)
		MFS	155..719	CDD:119392	128/669 (19%)
		Pentapeptide_3	507..561	CDD:290309	3/53 (6%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:16543415, ECO:0000269\|PubMed:27294781	529..566		0/36 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910