DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	134/529 - (25%)
Similarity:	230/529 - (43%)	Gaps:	22/529 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQ-IRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKEL 159
            |:|||..:|..|||| |::.:.:.|...:.:...| |.|....|| ::|..|...:...:...|.
  Rat     3 FNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTL-QNFTAAIPP-HHCRPPANANLSKDGGLEA 65

  Fly   160 SIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAFESATM-EFGW 223
            .:|.:|.|....|..:.:......|.....|  |.:..|.||..|:|::..  .|.|..: |:..
  Rat    66 WLPLDKQGQPESCLRFTSPQWGPPFYNGTEA--NGTRVTEPCIDGWVYDNS--TFPSTIVTEWNL 126

  Fly   224 LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFTFAIS 288
            :|....:...||.::.:|.:||.:.:|:.||..||...|:.:.....|.....:.:.::..:.:.
  Rat   127 VCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVF 191

  Fly   289 RFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWRRFSSFTS 353
            |.|.|.|..:.......|.:|::....|..|..| :...||....::..||.:..:||......|
  Rat   192 RLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTL-IGYVYSLGQFLLAGIAYAVPHWRHLQLVVS 255

  Fly   354 LPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASCTQFYKE-EL 417
            :|..:|........|||||..|.|.:|..|..|:.|..:|.||.....|.: |...|...|| .|
  Rat   256 VPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSI-EVLRTSLQKELTL 319

  Fly   418 DGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSE----NIFLFFTIACATEL 478
            .....:.:.:.:...:....:.:.::|.:.|..|.|     .|:|.:    :::|...|..|.:|
  Rat   320 SKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYG-----LVMDLQGFGVSMYLIQVIFGAVDL 379

  Fly   479 PGNILVILTLDRAGRRWCSFFYTSLSGVFSLL-GASFQNRANMRMS-ALAGRFFSNICYNIGLQW 541
            |...:..|.::..|||........|:|:..|: |...::...:|.| |:.|:......:|....:
  Rat   380 PAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCLASSFNCIFLY 444

  Fly   542 AAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFLPETLN 606
            ..|:.|||:|..|:....||..|..::||.|...::...|..|.:.||:.:....:...|||||.
  Rat   445 TGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLG 509

  Fly   607 HELPETLSD 615
            ..||:|:.|
  Rat   510 QPLPDTVQD 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	128/516 (25%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	90/377 (24%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	128/516 (25%)
		MFS	135..505	CDD:119392	90/376 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950