DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Slc22a29

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_766364.1	Gene:	Slc22a29 / 236293	MGIID:	3605624	Length:	551	Species:	Mus musculus

Alignment Length:	564	Identity:	145/564 - (25%)
Similarity:	242/564 - (42%)	Gaps:	60/564 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 IDFDDLLPMIGQFGRFQIR--LFLFMIPFCFITAFV--YLGQIFMCLTPPKYYCYVP-------- 146
            :.|.:||..:|..|||||.  :|||:     :.|.|  ::|........|.:.|:||
Mouse     1 MSFQELLNQVGSLGRFQILQIVFLFL-----LNAIVVPHIGMENFTAAIPNHRCWVPILDNDTAS 60

  Fly   147 ----ELLHTPVELRKELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLP-TIPCKKGYV 206
                .:|.....||  :|||.:.:....:||.:  ...:.|.......:.|.|.| |.||..|:|
Mouse    61 DNGSRILSQDDLLR--ISIPLDSNLRLDKCRRF--AQPQWHLLHLNGTFSNVSEPDTEPCVDGWV 121

  Fly   207 FEQEGRAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALV 271
            ::: .....:...|:..:|:.....:..:..|.:|..:||:..||.:|..||...|..:.....:
Mouse   122 YDR-SNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAI 185

  Fly   272 GSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMP 336
            .....:.:..||.:...|||.|.|.:......::|:||:..||:..::|.||.......| |::.
Mouse   186 TETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGF-MILA 249

  Fly   337 WIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEI 401
            .:|.....|.......|.||...:.....|.||||||:.:.:..|.|:.|:.|..:|..:.|.::
Mouse   250 GLAFLFRIWHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVAHMNGMKNSGDL 314

  Fly   402 -LDLFEASCTQFYKEELDG-------RDFTVLSIFKRKRMARYMILMILIWMSISL----VYDGH 454
             :::...|    .|.||:.       ||....||. |||:.  ::..|.::.::|:    |:..|
Mouse   315 TMEIVRTS----MKAELEAAKTKPSLRDLFHTSIL-RKRIC--VLSFIRLFFTVSIIGLAVHLQH 372

  Fly   455 VRAASVLDSENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASF--QNR 517
            :       |.||.|...:..|..:..:::....|:..|||.......||.|:|.:: |.|  |..
Mouse   373 L-------SSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMI-AVFVPQEM 429

  Fly   518 ANMR--MSALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSL 580
            ..:|  |:.|||. .|::|..:......|:|||.:||..:..|...|...:.:||..:.::....
Mouse   430 QTLRIIMATLAGG-ISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYA 493

  Fly   581 SSTLIVLGALGIFGGLLALFLPETLNHELPETLSDGAQFGKNQR 624
            :...|..|...||.......||||.|..||::..|.....|..|
Mouse   494 NLPWIFYGGFSIFNAFTVFLLPETKNQPLPDSTHDVGNDWKESR 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	139/540 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	97/386 (25%)
Slc22a29	NP_766364.1	MFS_OAT	109..515	CDD:340932	106/423 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843949
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940