DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Slc22a22

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	XP_036015188.1	Gene:	Slc22a22 / 210463	MGIID:	2446114	Length:	587	Species:	Mus musculus

Alignment Length:	612	Identity:	143/612 - (23%)
Similarity:	238/612 - (38%)	Gaps:	149/612 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 IDFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTP-----------PKYYCYV-- 145
            :|||::|..:|..|||||         |.|   :.|..:.:.|:|           |.::|.:
Mouse     1 MDFDEILHHVGDSGRFQI---------CMI---ILLNILSLVLSPHDVLENFTAAIPAHHCSINL 53

  Fly   146 --------PELLHTPVELRKELSIPKEKDGSYSRCRMYNTNYTKIHFAE-NPSAYINTSLPTIPC 201
                    .::..|..:|.| :|||...:....:||.:  .||:..|.: |.|.:.:|.|.|.||
Mouse    54 DNSRSEVSTDMNLTTEDLMK-VSIPMGPNQKPEQCRRF--RYTQWQFLDSNISTFNSTELETEPC 115

  Fly   202 KKGYVFEQ---------EG-----------------------RAFESATMEFGWLCDDDKYATYA 234
            ..|:.::.         ||                       ...:|:...:..:||...:..||
Mouse   116 LDGWTYDHSVFTSTIVTEGLSPPQPWDSDQYYHTKHEISPCEEGLKSSVKVWDLVCDFQSFKYYA 180

  Fly   235 QIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLAT--SMSTDFFTFAISRFLVGASYD 297
            |.....|.::.....|..:|..|| ..|:..|.|| .|::.|  :.:.:|..:.:.|||:.|...
Mouse   181 QATSLAGHLVSCPLSGIISDRFGR-KPLLMYCSLA-YGAVGTYCAFAPNFSVYCVLRFLLSAFQS 243

  Fly   298 TCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWRRFSSFTSLPIVLAMFS 362
            |......|||||....::...:..|| .||.|....|:..:|....:|.......:||..:....
Mouse   244 TILINSLILVLEEASVQWHPTIIVLS-GLFNSIGQGVLGGLAYVISDWHLLQLAYALPFFIFFVL 307

  Fly   363 FCLLPESARWLVSVGEIDKALEILKNVIEVN-KKQVSKEILDLFEASCTQFYKEEL------DGR 420
            ||.:|||.|||:..|:.|:|.:.|:.:..:| ||.:::.:       .|:..:.:|      .|:
Mouse   308 FCWVPESVRWLIITGKTDQAWKELQRIASINGKKGIAQNL-------TTEDLRSKLKKDVNSTGK 365

  Fly   421 DFTVLSIF-----KRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIFLFFTIACATELPG 480
            .|.:..||     ::..::...:|...::..:.|:.|..      |..:|:||......|.::|.
Mouse   366 LFRIKDIFINPLIRKIVLSNSSLLFAELFSFVGLLLDVQ------LLGKNMFLTQIFLGAIDVPS 424

  Fly   481 NILVILTLDRAGRRWCSFFYTSLSG------------------VFSLLGASFQNRANMRMSALAG 527
            ..|...|:....||....|....:|                  :..:||              .|
Mouse   425 KSLTYFTIRNVSRRPLIAFLLLTTGSCITITIFISEEMYVLRTIIFILG--------------KG 475

  Fly   528 RFFSNICYNIGLQWAAEILPTVVRA--QGV--AFIHTMGFVAMLMSPP---VVYLSKKSLSSTLI 585
            .|.:..|  |...:..|:.|..:|:  .||  |.:...|.::.|....   .|||       .:|
Mouse   476 CFAAFTC--ISTTYINELSPVELRSTLNGVFLAVVRLAGVLSALTLATRKYFVYL-------PMI 531

  Fly   586 VLGALGIFGGLLALFLPETLNHELPET 612
            :.|.|.|...:..||||||.|  ||.|
Mouse   532 LYGVLPIVATISILFLPETFN--LPHT 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	138/600 (23%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	94/409 (23%)
Slc22a22	XP_036015188.1	MFS_OAT	108..548	CDD:340932	105/478 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844065
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940