DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	546	Identity:	142/546 - (26%)
Similarity:	230/546 - (42%)	Gaps:	68/546 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQ-IRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKEL 159
            |.::|..:|..|.|| :.:.|..:|...|.....| |||.. |.|.::|..|     |....:..
Mouse     3 FSEILDRVGSMGPFQYLHVTLLALPILGIANHNLL-QIFTA-TTPDHHCRPP-----PNASLEPW 60

  Fly   160 SIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLP------TIPCKKGYVFEQEGRAFESAT 218
            .:|...:|...:|         :.|...|    |.|||      |.||..|:::..   ..::..
Mouse    61 VLPLGPNGKPEKC---------LRFVHLP----NASLPNDTQGATEPCLDGWIYNS---TRDTIV 109

  Fly   219 MEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFF 283
            .|:..:|..:|....||.:|..|.::||..:|..:|..||...|..|..|......:.:.|....
Mouse   110 TEWDLVCGSNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLT 174

  Fly   284 TFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWRRF 348
            .:.|.|||.|.|.........||.:|:| |.....:::.::...|:....::|.:|.:...||
Mouse   175 VYMIFRFLCGCSISGISLSTIILNVEWV-PTSTRAISSTTIGYCYTIGQFILPGLAYAVPQWR-- 236

  Fly   349 SSFTSLPIVLAMFSFCLL----PESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASC 409
              :..|.:..|.|.|.||    |||.||||..|:..|||:.|:.|...|.|:...|.|.:
Mouse   237 --WLQLSVSAAFFIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKEEGEKLTV----- 294

  Fly   410 TQFYKEELD---GRDFT-------VLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLD-S 463
                 |||.   .:|.|       :..:|:...:.|....:.|.|.:....|  :..|..|.: .
Mouse   295 -----EELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFATGFAY--YSLAMGVEEFG 352

  Fly   464 ENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASFQNRANMRMSALAGR 528
            .||::...|....::|...:.||::...|||....|...|:|| ::|...|.: :.|::...|..
Mouse   353 VNIYILQIIFGGVDIPAKFITILSISYLGRRITQGFLLILAGV-AILALIFVS-SEMQLLRTALA 415

  Fly   529 FFSNIC----YNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGA 589
            .|...|    ::....:.:|:.|||:|..|:...:....|..:::|.|....:.......::.|.
Mouse   416 VFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGT 480

  Fly   590 LGIFGGLLALFLPETLNHELPETLSD 615
            :.:.||..|.||.||||..||||:.|
Mouse   481 MTLLGGSAAFFLLETLNRPLPETIED 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	137/533 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	98/389 (25%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	137/533 (26%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844028
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950