DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10486 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus

Alignment Length:	534	Identity:	133/534 - (24%)
Similarity:	231/534 - (43%)	Gaps:	38/534 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQ-IRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKEL 159
            |:|||..:|..|||| |::.:.:.|...:.:...|......:  |.::|..|...:...:...|.
Mouse     3 FNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAI--PAHHCRPPANANLSKDGGLEA 65

  Fly   160 SIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAFESATM-EFGW 223
            .:|.:|.|....|       .:..|..|.:....|.: |.||..|:|::..  .|.|..: |:..
Mouse    66 WLPLDKQGRPESC-------LRFPFPHNGTEANGTGV-TEPCLDGWVYDNS--TFPSTIVTEWNL 120

  Fly   224 LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFTFAIS 288
            :|....:...||.:|.:|.:||.:.:|:.||..||...|:.:.....|.....:.:.::..:.|.
Mouse   121 VCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIF 185

  Fly   289 RFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWRRFSSFTS 353
            |.|.|.|..:.......|.:|::....|..|..| :...||....::..||.:..:||......|
Mouse   186 RLLSGMSLASIAINCMTLNMEWMPIHTRAYVGTL-IGYVYSLGQFLLAGIAYAVPHWRHLQLAVS 249

  Fly   354 LPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQ-----VSKEILDLFEASCTQFY 413
            :|..:|........|||||..|.|.:|..|..|:.|..:|.||     :|.|:|.      |...
Mouse   250 VPFFVAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLQ------TSLQ 308

  Fly   414 KE-ELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSE----NIFLFFTIA 473
            || .|:....:.:.:.:...:.|..:.:.::|.:.|..|.|     .|:|.:    :::|...|.
Mouse   309 KELTLNKGQASAMELLRCPTLRRLFLCLSMLWFATSFAYYG-----LVMDLQGFGVSMYLIQVIF 368

  Fly   474 CATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLL-GASFQNRANMRMS-ALAGRFFSNICYN 536
            .|.:||...:..|.::..|||........|:|:..|: |...:....:|.| |:.|:......:|
Mouse   369 GAVDLPAKFVCFLVINSMGRRPAQLASLLLAGICILVNGIIPRGHTIIRTSLAVLGKGCLASSFN 433

  Fly   537 IGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFL 601
            ....:..|:.||::|..|:....||..|..::||.:...::...|..|.:.||:.:....:...|
Mouse   434 CIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLISMTAEFYPSIPLFIFGAVPVAASAVTALL 498

  Fly   602 PETLNHELPETLSD 615
            ||||...||:|:.|
Mouse   499 PETLGQPLPDTVQD 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	127/521 (24%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	92/382 (24%)
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	127/521 (24%)
		MFS	129..499	CDD:119392	92/381 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950