DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and K05F1.6

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001342018.1	Gene:	K05F1.6 / 173977	WormBaseID:	WBGene00019408	Length:	858	Species:	Caenorhabditis elegans

Alignment Length:	719	Identity:	167/719 - (23%)
Similarity:	288/719 - (40%)	Gaps:	133/719 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 EKVKVTYVEPDDEESSHGFFWGKKKSETSLPRRSWETDDYIDFDDLLPMIGQFGRFQIRLFLFM- 117
            :||:..|.:.:.:|                 |:..:..|.|||:.:|.:||....:||.:::.:
Worm   177 QKVQQIYRDVNKKE-----------------RKEGKPTDPIDFEGILNIIGGCRWWQIWIYVLIA 224

  Fly   118 ---IPFCFITAFVYLGQIFMCLTPPKYYCYVPEL---------LHTP----VELRKELS--IPK- 163
               ||.    |...|..::| :..|::.|.||..         .|.|    |:..|.:|  .|.
Worm   225 LQQIPH----AMFNLNVVYM-MYDPEFQCMVPGFNDTNDTTISSHGPYLWGVDDIKNISFVFPNA 284

  Fly   164 EKDGSYSR--CRMYNTN---YTKIHFAENPSAYINTSLPTIPCKK--GYVFEQEGRAFESATMEF 221
            ..||:|.|  |..|..:   |.::......:|.........|.||  .|.||::... |:...:|
Worm   285 NSDGAYQRDSCYFYERSEERYRQLRRMPLETAMSEAWKDVAPKKKCQAYHFEKDVMV-ETIVTDF 348

  Fly   222 GWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFTFA 286
            ..:||......:|.:.:.:|.:||.:..|..:|..||...::....|:.:..:....:..:..|.
Worm   349 NLVCDSWFAKGHAHMFYSIGYLLGCVLGGIASDKIGRKPTIIGFGILSSMLGVFLPFNDYYPMFL 413

  Fly   287 ISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPW---------IALSA 342
            :.|.|.....:......|.|.:|..|.|||.:|.::..|          ||         ||...
Worm   414 LIRLLSAICNEAADLAAYTLCMEITGTKYRAMVGSMLQA----------PWALGYALLALIAYLT 468

  Fly   343 GNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILK----------NVIEVNKKQV 397
            .:|:......:....:::...|.:|||.|||:....:.:|.|:::          |:...:|...
Worm   469 KSWKTIQVIAAGLHFMSIIFICSIPESPRWLMVQNRVSEAEEVIRKACREPPFPFNMCTTSKCGN 533

  Fly   398 SKEILDLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLD 462
            ....|:|......:..|:  :|.....|.:|..|.:....|.:.:::|:.:|||.|.|.|.|...
Worm   534 LPSDLELVSHRERKLNKK--NGGKIGFLDLFTMKELRYRTISVCIVFMATALVYYGLVMALSDQS 596

  Fly   463 SENIFLFF-------TIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASFQNRANM 520
            :....||.       .||.|.|:| .:...:.:.:.||:.........||:| ::.|.....:..
Worm   597 APGRTLFTGYFHLNNGIAGAIEIP-TLFACVWMMQLGRKKALMLTLITSGLF-IIVAMLSMVSGH 659

  Fly   521 RMSALAGRFFSNI----CYNIGLQWAAEILPTVVR--AQGV-AFIHTMG-----FVAML--MSPP 571
            .|.|||..:|..|    .:||...:.:|:.|||||  |.|| :.:...|     ::|:|  :|.|
Worm   660 YMLALAFMYFGKIAVQGAFNILYIFTSELYPTVVRNTAVGVTSMVARFGSGLSSYIALLSNISLP 724

  Fly   572 VVYLSKKSLSSTLIVLGALGIFGGLLALFLPETLNHELPETLSDGAQF-----------GKNQRI 625
            :|         .:|:.....:|.|:|...||||....|||||.|...|           |:....
Worm   725 IV---------PMIIFAVFSLFAGMLVFVLPETSEKPLPETLDDAINFLEPTKQVNCMMGRFGVF 780

  Fly   626 WHMPCCGPGSRKSHPRHNWHQGSSLRTLSKDEFRSSKMYRKTKYR----FESHPSPSSSDYKGTE 686
            .|.......|...:|..|  ..:.|:.||:   |||.:.|:...|    :..:.|.::|..:..:
Worm   781 GHQKMTKSISLTENPSTN--DIADLKPLSR---RSSAITRRMTERASVIYSRNASRTNSIVQDIQ 840

  Fly   687 EKEI 690
            :.:|
Worm   841 DIQI 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	135/574 (24%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	93/410 (23%)
K05F1.6	NP_001342018.1	MFS_SLC22	333..746	CDD:340875	100/436 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163148
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840