DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Slc22a27

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	XP_017173565.1	Gene:	Slc22a27 / 171405	MGIID:	3042283	Length:	576	Species:	Mus musculus

Alignment Length:	562	Identity:	145/562 - (25%)
Similarity:	235/562 - (41%)	Gaps:	56/562 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 IDFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFV--YLGQIFMCLTPPKYYCYVP---------- 146
            :.|.:||..:|..|||||...:|::   .:.|.|  ::.........|.:.|:||
Mouse    26 MSFQELLNQVGSLGRFQILQIVFLL---LLNAIVVPHIAMENFTAAIPNHRCWVPILDNDTASDN 87

  Fly   147 --ELLHTPVELRKELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLP-TIPCKKGYVFE 208
              .:|.....||  :|||.:.:....:||.:  ...:.|.......:.|.|.| |.||..|:|::
Mouse    88 GSRILSQDDLLR--ISIPLDSNLRPEKCRRF--AQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYD 148

  Fly   209 QEGRAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGS 273
            : .....:...|:..:|:.....:..:..|.:|..:||:..||.:|..||...|..:.....:..
Mouse   149 R-SNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRLGRKFILTCALLQFAITE 212

  Fly   274 LATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFT--MVMP 336
            ...:.:..||.:...|||.|.|.:......::|:||:..||:.|::|.|   |..:|..  |:..
Mouse   213 TCVAFAPSFFIYCSLRFLAGLSVEPILVNSHLLMLEWTSPKFLTMMAAL---LSCAPNIGYMISA 274

  Fly   337 WIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEI 401
            .:|.....|.......|:||...:.....|.||||||:...:..|.|:.|:.|..:|..:.|.::
Mouse   275 GLAFLFRIWHHLQLTMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKVAHMNGMKNSGDL 339

  Fly   402 -LDLFEASCTQFYKEELDG-------RDFTVLSIFKRKRMARYMILMILIWMSI--SLVYDGHVR 456
             :::...|    .|.||:.       ||....||. |||:.....:.:...:||  ..|:..|:
Mouse   340 TMEIVRTS----MKAELEAAKTKPSLRDLFHTSIL-RKRICVLSFMRLFFTVSIFGLAVHLQHL- 398

  Fly   457 AASVLDSENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASF--QNRAN 519
                  |.||.|...:..|..:..:::....|:..|||.......||.|:|.|: |.|  |....
Mouse   399 ------SSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFILI-AVFVPQEMQT 456

  Fly   520 MR--MSALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSS 582
            :|  |:.|| ...|::|..:......|:|||.:||..|..|...|.....:||..:.|:....:.
Mouse   457 LRIIMATLA-EGISSLCVGVSRLHTNELLPTTLRATAVGVIGFFGNSGSFLSPLFMLLATYYANM 520

  Fly   583 TLIVLGALGIFGGLLALFLPETLNHELPETLSDGAQFGKNQR 624
            ..|..|...||.......||||.|..||::..|.....|..|
Mouse   521 PWIFYGGFSIFNAFTVFLLPETKNQPLPDSTHDVGNDWKESR 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	139/538 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	100/386 (26%)
Slc22a27	XP_017173565.1	MFS_OAT	134..540	CDD:340932	109/423 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843937
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940