DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Ust5r

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_599207.2	Gene:	Ust5r / 171398	RGDID:	620985	Length:	552	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	143/563 - (25%)
Similarity:	236/563 - (41%)	Gaps:	79/563 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQI--RLFLFMI-----PFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPV 153
            |.:||..:|..|||||  ..|:|:|     |...|..|.        ...|.:.|:||.|.:..|
  Rat     3 FQELLNQVGSLGRFQILQMAFVFLINVSVVPHSTIENFT--------AAIPSHRCWVPILDNVTV 59

  Fly   154 E------LRKE----LSIPKEKDGSYSRCRMY----------NTNYTKIHFAENPSAYINTSLPT 198
            .      |.::    :|||.:......:||.:          |..::.:           |...|
  Rat    60 SDNHSRILNQDKLLKISIPLDSHLRLDKCRRFAQPQWHLLDLNDTFSSV-----------TEADT 113

  Fly   199 IPCKKGYVFEQEGRAFESATM-EFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAAL 262
            .||..|:|:::..  |.|.|: |:..:|:.....:..:..|.:|:.:||:..|..:|..||...|
  Rat   114 EPCVDGWVYDRSN--FHSTTVTEWDLVCESQVLNSVTKFSFMIGAFIGGIVNGPLSDRFGRKFVL 176

  Fly   263 VSSCFLALVGSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALF 327
            ..:.....:.......:::||.:...|||.|.:::.......:|:.|:...|:..:::  .:|..
  Rat   177 KCALLQMAITETCVGFASNFFIYCSLRFLAGMTFEPILVNSNLLMFEWTSHKFLAMMS--VIAPC 239

  Fly   328 YSPF-TMVMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIE 391
            ...| :|::..:|....||.......|:||...:.....|.||||||:...:..|.|:.|:.|..
  Rat   240 AGSFGSMILAGLAFQFQNWHHLQLAMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKVAH 304

  Fly   392 VNKKQVSKEILDLFEASCTQFYKEELDG-------RDFTVLSIFKRKRMARYMILMILIWMSI-- 447
            :|..:.|.:.|.: |...|.. |.||:.       ||.....|. |||:.....:.||..:||
  Rat   305 MNGMKNSGDNLTM-EVVRTSM-KRELEAAKARPSPRDLFHTPIL-RKRICAMSFMRILFMLSIFG 366

  Fly   448 -SLVYDGHVRAASVLDSENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLG 511
             ||    |::..    |.||.|...:..|:.|..:::.....:|.|||.......:|.|: .:|.
  Rat   367 MSL----HLQHL----SSNIMLLQFVVSASSLLFSVIGPYVFNRMGRRITQMVVMTLRGI-CILT 422

  Fly   512 ASF--QNRANMRMS--ALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPV 572
            |.|  |....:|::  .|||. ||.:.:.:......|:|||.:||..:..|...|.....::|..
  Rat   423 AVFVPQEMQILRITVVTLAGA-FSALSFGVNRLHTNELLPTTLRATAIGVIGMFGNSGFFLAPLF 486

  Fly   573 VYLSKKSLSSTLIVLGALGIFGGLLALFLPETLNHELPETLSD 615
            :.|:..|.:...|..|...|..|.....||||.|..||:.:.|
  Rat   487 MILASYSPNLPWIFYGGFSILNGFTVFLLPETKNQPLPDCIHD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	139/550 (25%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	96/385 (25%)
Ust5r	NP_599207.2	MFS_OAT	109..516	CDD:340932	107/423 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940