DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10486 and Sv2a

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_476558.2	Gene:	Sv2a / 117559	RGDID:	619715	Length:	742	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	108/567 - (19%)
Similarity:	181/567 - (31%)	Gaps:	213/567 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFTFAIS 288
            :|..|.......:|.:||.::|...:|..||..||...|:.|..:..|.:..:|....:.||...
  Rat   197 MCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFC 261

  Fly   289 RFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLS-LALFY---SPFTMVMPWI----------- 338
            |.|.|........:|:....|::..:.|.  .:|| |.:|:   ..:...|.|.
  Rat   262 RLLSGVGIGGSIPIVFSYFSEFLAQEKRG--EHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQM 324

  Fly   339 --ALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKK------ 395
              |....:||.|....:.|.|.|:.:....|||.|:.:..|:.|:|..:||.|.:.|.:
  Rat   325 GSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPE 389

  Fly   396 -----------QVSKEILDLFEASCTQFYKE------ELDGRDF-TVLSIFKRKRMARYMILMIL 442
                       ....|:::: ::....:|:.      .|.|:.: ..||.|. ....|..::|:.
  Rat   390 RVFSVTHIKTIHQEDELIEI-QSDTGTWYQRWGVRALSLGGQVWGNFLSCFS-PEYRRITLMMMG 452

  Fly   443 IWMSISLVYDG------------------------------HV---------------------- 455
            :|.::|..|.|                              ||
  Rat   453 VWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFI 517

  Fly   456 --RAASVLDSENIF------------LFF-------TIACATE---------------------- 477
              |..||...:::|            .||       |:...|:
  Rat   518 GLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEG 582

  Fly   478 --------------------------LPGNILVILTLDRAGRRWCSFFYTSLSG--VFSLLGASF 514
                                      |||||:..|.:|:.||      ...|:|  |.|.:...|
  Rat   583 CPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGR------LRMLAGSSVLSCVSCFF 641

  Fly   515 QNRANMRMSALAGRFFSNICYNIGL---QWAA------EILPTVVRAQGVAFIHTM--------- 561
            .:..|...:.:|     .:|...|:   .|.|      |:.|:..|.....|::.:
  Rat   642 LSFGNSESAMIA-----LLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGI 701

  Fly   562 ----GFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFLPET 604
                .||.:..:.|:::.|           .||.: |..|||.||||
  Rat   702 SIFTSFVGITKAAPILFAS-----------AALAL-GSSLALKLPET 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	108/567 (19%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	102/556 (18%)
Sv2a	NP_476558.2	synapt_SV2	1..742	CDD:130366	108/567 (19%)
		Interaction with SYT1	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..145
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910