Protein Alignment CG10486 and SLC22A7

DIOPT Version :9

• Sequence 1: NP_647998.2
• Gene: CG10486 / 38664
• FlyBaseID: FBgn0035647
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: XP_011512558.1
• Gene: SLC22A7 / 10864
• HGNCID: 10971
• Length: 610
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 147/613 - (23%)
• Similarity: 256/613 - (41%)
• Gaps: 120/613 - (19%)

  Fly    96 FDDLLPMIGQFGRFQIR-LFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVP----ELLHTPVEL 155
            |::||..:|.||.||:| :.|..:|...:... :|..||:... |.:.|.:|    ...|..|.|
Human     3 FEELLEQVGGFGPFQLRNVALLALPRVLLPLH-FLLPIFLAAV-PAHRCALPGAPANFSHQDVWL 65

  Fly   156 RKELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSL--------------PTIPCKKGYV 206
              |..:|:|.||:.|.|         :.|| .|.|..||:|              .|:||.:|:.
Human    66 --EAHLPREPDGTLSSC---------LRFA-YPQALPNTTLGEERQSRGELEDEPATVPCSQGWE 118

  Fly   207 FEQ-----------------------------------EGRAFESAT------------------ 218
            ::.                                   .|..:|.|.
Human   119 YDHSEFSSTIATESQVGIYIIHLEVECRWRQSPWEAAGRGLPWEEAEAAGLGRDKVSYSPSWRES 183

  Fly   219 -------MEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLAT 276
                   ||:..:|:.......|...||.|.::|.:|:|:.:|..||...|:.:....||..||:
Human   184 LGGLLSGMEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLAS 248

  Fly   277 SMSTDFFTFAISRFLVGASYDTCFTMVYILV----LEYVGPKYRTLVANLSLALFYSPFTMVMPW 337
            :.|..:..|||:|.|.|::. ..||::.:.:    ||::..::||:...|| :.|::...|::..
Human   249 AASVSYVMFAITRTLTGSAL-AGFTIIVMPLGEAELEWLDVEHRTVAGVLS-STFWTGGVMLLAL 311

  Fly   338 IALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEIL 402
            :.....:||......:||....:.|...:|||||||::.|.:.:|...|.:...:|.:.|.::
Human   312 VGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCED-- 374

  Fly   403 DLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIF 467
            ...:.:.::....|...|..:.|.:|:..|:....:..:::|..::..|.|.....|.| ..|::
Human   375 SFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGL-GLNVY 438

  Fly   468 LFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASFQNRANMRMS--------- 523
            ....:..|.|||..:||.|::..||||        |:...:|||.:......:.:|
Human   439 QTQLLFGAVELPSKLLVYLSVRYAGRR--------LTQAGTLLGTALAFGTRLLVSSDMKSWSTV 495

  Fly   524 -ALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVL 587
             |:.|:.||...:.....:.:|:.|||:|..|:.....:|.:...::|....|....||...:..
Human   496 LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTY 560

  Fly   588 GALGIFGGLLALFLPETLNHELPETLSD 615
            |.:.:.....||.||||...:||||:.|
Human   561 GGIALLAAGTALLLPETRQAQLPETIQD 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	141/600 (24%)
		MFS	231..602	CDD:119392	94/384 (24%)
SLC22A7	XP_011512558.1	2A0119	11..585	CDD:273328	141/600 (24%)
		MFS	206..563	CDD:119392	92/369 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153787
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860