DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_659105.2	Gene:	Slc22a7 / 108114	MGIID:	1859559	Length:	540	Species:	Mus musculus

Alignment Length:	556	Identity:	148/556 - (26%)
Similarity:	258/556 - (46%)	Gaps:	58/556 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQIR-LFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPE----LLHTPVEL 155
            |::||..:|.||.||:| |.|..:| .|:....:|..|||... |.::|.:|:    |.|..:.|
Mouse     3 FEELLHKVGGFGPFQLRNLVLLALP-RFLLPMHFLLPIFMAAV-PAHHCALPDAPANLSHQDLWL 65

  Fly   156 RKELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLP--------------TIPCKKGYV 206
            :..|  |:|.|||:|.|         :.|| .|.|..|.:|.              |:||.:|:.
Mouse    66 KTHL--PRETDGSFSSC---------LRFA-YPQALPNVTLGTEVYNSGEPEGEPLTVPCSQGWE 118

  Fly   207 FEQEGRAFESATMEFGW--LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLA 269
            ::   |:..|:|:...|  :|............||:|.:||.:.||:.:|..||...|:.:....
Mouse   119 YD---RSEFSSTIATEWDLVCQQRGLNKVTSTCFFIGVLLGAVVYGYLSDRFGRRRLLLVAYVST 180

  Fly   270 LVGSLATSMSTDFFTFAISRFLVGASYDTCFTMVYI-LVLEYVGPKYRTLVANLSLALFYSPFTM 333
            |...|.::.|.::..|..:|.|.|::. ..||::.: |.||::..::|| ||.:....|::...:
Mouse   181 LALGLMSAASVNYIMFVTTRMLTGSAL-AGFTIIVLPLELEWLDVEHRT-VAGVISTTFWTGGVL 243

  Fly   334 VMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVS 398
            ::..:.....:||......:||.|..:.|...:|||||||::.|.:::|.:.|....::|.:.:|
Mouse   244 LLTLVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLSICAKLNGRPIS 308

  Fly   399 KEILDLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAAS---- 459
            ::.|.. ||.......|.:..|. :.|.:|:..::....:..:::|..::..|.|....||
Mouse   309 EDSLSQ-EALNKVITMERVSQRP-SYLDLFRTSQLRHVSLCCMMMWFGVNFSYYGLTLDASGLGL 371

  Fly   460 -VLDSENIFLFFTIACATELPGNILVILTLDRAGRRWCS---FFYTSLSGVFSLLGASFQNRANM 520
             |..::.:|      .|.|:|..|.|...:...|||...   ...|:|:...||| .|...::.:
Mouse   372 TVYQTQLLF------GAVEVPSKITVFFLVRLVGRRLTEAGMLLATALTFGISLL-VSSDTKSWI 429

  Fly   521 RMSALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLI 585
            ....:.|:.||...:.....:.:|:.|||:|..|:.|...:|.:...::|.||.|....|....:
Mouse   430 TALVVIGKAFSEAAFTTAYLFTSELYPTVLRQTGMGFTALIGRLGASLAPLVVLLDGVWLLLPKL 494

  Fly   586 VLGALGIFGGLLALFLPETLNHELPETLSDGAQFGK 621
            ..|.:........|.||||...:||||:.|..:.|:
Mouse   495 AYGGISFLAACTVLLLPETKKAQLPETIQDVERKGR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	141/537 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	92/379 (24%)
Slc22a7	NP_659105.2	2A0119	11..521	CDD:273328	141/537 (26%)
Slc22a7	NP_659105.2	MFS	146..511	CDD:119392	92/375 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844015
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850