DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and slc22a13

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	XP_031760340.1	Gene:	slc22a13 / 100491580	XenbaseID:	XB-GENE-959647	Length:	547	Species:	Xenopus tropicalis

Alignment Length:	536	Identity:	152/536 - (28%)
Similarity:	256/536 - (47%)	Gaps:	49/536 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYC-------YVPELLHTP 152
            ||.::|..:|:|||||.:|.:.:....|:.||....|:||.: |..:.|       ..|.|  |.
Frog     3 DFAEILKNVGEFGRFQKQLVVVLSLLSFLNAFHMFSQVFMEI-PVPHRCDSRWILLINPNL--TE 64

  Fly   153 VELRKELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAFESA 217
            .| |...:||::..|.|.:|.||:.....:...|...  :|:   |.||:.|:.::...:.....
Frog    65 AE-RLNYTIPRDGRGQYEQCLMYSPVQWDMESIEKFG--LNS---TGPCQDGWEYDTSEQKSTLV 123

  Fly   218 TMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDF 282
            | :|..:|...:....:|.::..|.::|.|.:|...|..||...::.|..|.||..|:.:.:..|
Frog   124 T-QFDLVCHRREQTGISQSVYMSGLLIGALLFGPLGDRIGRRPVILLSMLLQLVFGLSAAFAPHF 187

  Fly   283 FTFAISRFLVGASYDTCFTMVYILVLEYVGPKYR---TLVANLSLALFYSPFTMVMPWIALSAGN 344
            :.:...|::||.|.........:|..|:||...|   |:.|::..|:    ..|.:..::....|
Frog   188 YVYTAFRWVVGTSMSGLMINNLVLGAEWVGSSRRACATITAHVCFAV----GLMALAGVSYGIRN 248

  Fly   345 WRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASC 409
            ||.....:|.|..|..|...:||||||||::.|:.:||:::||....:|||::.:::  ||:
Frog   249 WRLLQIVSSAPTALLFFYIWVLPESARWLLTKGKKEKAVKLLKKAAAMNKKEIPEDL--LFQ--- 308

  Fly   410 TQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDG-HVRAASV-LDSENIFLFFTI 472
               :.||...:...::.:|:.|.:.:..::|.|:|...||||.| .:...|. ||   |:|...:
Frog   309 ---FNEEKSPKSGNMIDLFRNKTLRKLTLVMCLVWFVNSLVYYGLSLNVGSFGLD---IYLTQLV 367

  Fly   473 ACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASFQNRANMRMSALA--GRF-----F 530
            ..|.|:|..|..:..:...||:....|...|.|...|:..:......:.::.||  |:|     |
Frog   368 FGAVEIPARIGAMFAVQLFGRKPSQMFCLFLGGTVCLIITAIPRNLPIAITILAVIGKFSIASSF 432

  Fly   531 SNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGG 595
            | |||    .:|||:.|||:|..||........||.:.:|.:..|.|...:..:.:.|:..|.||
Frog   433 S-ICY----IYAAEVFPTVIRQNGVGLASMAARVAGITAPLISLLDKYHAAIPMAIYGSGPIIGG 492

  Fly   596 LLALFLPETLNHELPE 611
            :|...||||.|.:|.:
Frog   493 ILCFLLPETRNKDLQD 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	149/527 (28%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	107/382 (28%)
slc22a13	XP_031760340.1	2A0119	12..509	CDD:273328	149/527 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9954
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010