DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and slc22a6

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	XP_002937540.1	Gene:	slc22a6 / 100487511	XenbaseID:	XB-GENE-5842250	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	550	Identity:	136/550 - (24%)
Similarity:	234/550 - (42%)	Gaps:	43/550 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQ-IRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYV----PELLHTPVEL 155
            |.::|..||..||:| |.:.|..:| .|:.|...|.|.|.... |::.|.:    .|...|...|
Frog     3 FQEILESIGGMGRYQVIHVVLLSLP-VFMLASHNLMQNFTAAI-PRHRCQINGSFEETNFTGPWL 65

  Fly   156 RKELSIPKEKDGSYSRCRMYNTNYTKI---HFAENPSAYINTSLPTIPCKKGYVFEQEGRAFESA 217
            |  ..:|.:..|.:|:|..|.|....:   :|.:|..     .|.|..|..|:|::....|   :
Frog    66 R--ALVPMKPTGEFSKCLRYTTPQYHLLMDNFTQNVD-----ELETETCVDGWVYDHSEFA---S 120

  Fly   218 TMEFGW--LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMST 280
            |:...|  :|:..:....||.|:..|.::|.:.:|..:|..||....:.|.....|..:..:.|.
Frog   121 TIITQWDLVCNHRRMRQVAQSIYMAGVLVGSVVFGGLSDKFGRRPLNIWSNLQMSVTGICAAFSP 185

  Fly   281 DFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNW 345
            ::..:.|.|||.|.:........|.|::|:: |.......:.:....|:...:|:..:|....:|
Frog   186 NYIWYCIFRFLTGTALSGIVLNSYSLIVEWI-PTGNRAFTSTATGYCYTMGQLVLVGLAFMIRDW 249

  Fly   346 RRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVN-KKQVSKEI-LDLFEAS 408
            .......|||..........:|||.||||..|:.:.|.:.||.|.::| ||:..::: :::.::|
Frog   250 HWLQLAASLPFFFYFLYSWWIPESGRWLVLSGKPEVACKALKKVAKINGKKEAGEKLTVEVLKSS 314

  Fly   409 CTQFYKEELDG---RDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSE----NI 466
                .:.|:..   ..::||.:.:...:.|....:...|.|.|..|.|     ..||.:    :|
Frog   315 ----MQREISASKHSTYSVLDLVRTPVVRRISFCISCTWFSTSFAYYG-----LALDLQSFGVSI 370

  Fly   467 FLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASF-QNRANMRMS-ALAGRF 529
            ::...|....::|........:...|||........|:|:..|:.... |:...:|.| |:.|:.
Frog   371 YIIQIIFGTVDIPAKFFSYFVMTYIGRRVLQALTLILAGIAILVNICVPQDYQTVRTSMAVFGKG 435

  Fly   530 FSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFG 594
            .....:|....:..|:.|||:|..|:.....|..:..:::|..........|..||:.|.|.|..
Frog   436 CLAASFNCLFLYTGELYPTVIRQSGMGLGTMMARLGGIIAPLAQMTGDIYHSLPLIIFGCLPILS 500

  Fly   595 GLLALFLPETLNHELPETLSDGAQFGKNQR 624
            |:...||||||...||||:.|.....|.|:
Frog   501 GIAGCFLPETLGVPLPETIEDVESSDKKQK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	128/528 (24%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	86/381 (23%)
slc22a6	XP_002937540.1	MFS_SLC22A6_OAT1_like	102..508	CDD:341004	95/418 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100