DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10486 and slc22a5

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	XP_002934410.2	Gene:	slc22a5 / 100486941	XenbaseID:	XB-GENE-484416	Length:	550	Species:	Xenopus tropicalis

Alignment Length:	550	Identity:	132/550 - (24%)
Similarity:	243/550 - (44%)	Gaps:	37/550 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKEL 159
            |:|.....:|::|.||:.:|..:........|..|..:|:..| |::.|::||..:.....| ..
Frog     3 DYDQATAFLGEWGPFQVSVFFLLSASIIPNGFTGLSAVFLAAT-PEHRCHIPESANLSAAWR-NA 65

  Fly   160 SIPKEKDGSYSRCRMYN----TNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAFESATME 220
            |||:: ||..|:||.|.    |||:.:.........: |.:...||..|:.: .:.....:...|
Frog    66 SIPRQ-DGQDSQCRRYRLGTLTNYSALGLLPGRDVDV-TGIEQEPCLDGWNY-SKSLYLSTIVTE 127

  Fly   221 FGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFTF 285
            :..:|::|........:||:|.::|....|..:|..||...|.::..:....|:....|.::..|
Frog   128 WNLVCENDWKGPLTTSLFFVGVLIGSFVSGQMSDRFGRKKVLFATMAVQTGFSIIQVFSVNWEMF 192

  Fly   286 AISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWRRFSS 350
            .....:||....:.:...:||..|.:....|.:.:.|.:.:||:...|::|..|....:||....
Frog   193 TALFIIVGMGQISNYVAAFILGAEILDKSVRIIFSTLGVCIFYAIGYMLLPLFAYFIRDWRTLLL 257

  Fly   351 FTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASCTQFYKE 415
            ..::|.:..:..:.::|||.|||:|.|...:|.:|::...:.|.......|.:..|..    .::
Frog   258 ALTIPGLFCIPLWWIIPESPRWLISQGRFQEAEDIIRKAAKKNGITPPDSIFNFTELQ----EQK 318

  Fly   416 ELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENI----FLFFTIACAT 476
            ||..:..|.|.:.|.:.:.....|.||:||.||:.|.|     ..|::.|:    ::...::...
Frog   319 ELTHKSHTFLDLLKTRNIRIITFLSILLWMIISVGYFG-----LSLNTPNLHGDPYVNCFLSAII 378

  Fly   477 ELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASFQNRANMRMSALA------GRFFSNICY 535
            |:|..::..|.|....||:.:.....|.||..|    |.......:..|:      |:|.....:
Frog   379 EVPAYVIAWLLLRSFPRRYSTASTLVLGGVVLL----FIQLVPQELGILSIVLVMLGKFGITSAF 439

  Fly   536 NIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALF 600
            ::...:.||:.|||||..||........:..::||..|||.........|::|:|.:..|:..|.
Frog   440 SMVYVYTAELYPTVVRNMGVGASSMASRMGSILSPYFVYLGAYDRFLPFILMGSLTVLIGMFTLC 504

  Fly   601 LPETLNHELPETLSD-----GAQFGKNQRI 625
            |||:....||:|:.:     |.::...:|:
Frog   505 LPESHGMPLPDTIEEMLRVKGFRYKAGKRL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	127/521 (24%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	89/380 (23%)
slc22a5	XP_002934410.2	2A0119	12..516	CDD:273328	127/521 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100