DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and slc22a13a

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	XP_021322911.1	Gene:	slc22a13a / 100007819	ZFINID:	ZDB-GENE-070912-473	Length:	537	Species:	Danio rerio

Alignment Length:	547	Identity:	141/547 - (25%)
Similarity:	245/547 - (44%)	Gaps:	49/547 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKE- 158
            :|.::|..||.||.|| :|.||.:.|..:.....|..:........::|....:|.....|.||
Zfish     3 NFGEILEAIGDFGLFQ-KLLLFALCFPNLILPFQLSSLVFNHADTNHHCNTDWILKADPNLTKEE 66

  Fly   159 ---LSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSL-PTIPCKKGYVFEQEGRAFESATM 219
               |::|:..|||::.|:||..      ...|.||.....| .|..|..|:|  .....:|:..:
Zfish    67 QLNLTLPRLSDGSFNPCQMYKP------VDWNLSAIQEYGLNQTTTCTDGWV--HNDTIYEATIV 123

  Fly   220 -EFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFF 283
             :|..:|::......||.:||.|.::|.:.:|.|::..||..|......|.|:.::.|.:|.:|:
Zfish   124 TDFDLVCENVNIFRGAQTVFFAGVLVGAILFGPFSESFGRKRATQIPMVLMLIFTVVTGLSPNFY 188

  Fly   284 TFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLS---LALFYSPFTMVMPWIALSAGNW 345
            .:.:|:|:.|...........||..|::|...|:..|.||   .||....|..|:.::.    :|
Zfish   189 VYLVSQFINGVGLGGFRINSIILASEWIGVAQRSYAACLSQVLAALGQVMFLAVVYFVR----DW 249

  Fly   346 RRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASCT 410
            |......:.||.:.:.....||||||||:..|....|.::::....|||:.|.:.:::
Zfish   250 RLDQFIMAGPIGIVVIYIWFLPESARWLLDRGRTKDAKKLIQKAAAVNKRAVPESLVE------- 307

  Fly   411 QFYKE---ELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASV----LDSENIFL 468
            :..||   |..|    :..:|..:.:.:|.:.:...|.:::|.|  :..:.:|    ||   |||
Zfish   308 EVLKEKPVEKGG----IKILFGSRVLRKYFLAITFAWCALNLAY--YSLSLNVGKFGLD---IFL 363

  Fly   469 FFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASFQNRANMRMSALA--GRFFS 531
            ...|...:|:|.:.|.:.:|:..||:........|.|...||..:....:::.::.||  |||..
Zfish   364 TQLIFGLSEIPVHFLCMWSLEVVGRKPSLIVSLVLGGCLCLLTVAVPQNSSIAIAVLATCGRFLM 428

  Fly   532 NICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGL 596
            |...::...:..|:.||.:|........|......::||.|..|.....|..::|:.:|.:..|:
Zfish   429 NAAGSVCNVYFQELFPTSIRQTATGLGSTAARAGSMLSPVVNMLEIFHFSIPMVVISSLALASGV 493

  Fly   597 LALFLPETLNHELPETLSDGAQFGKNQ 623
            .|..||||...|||.:..:..  ||.:
Zfish   494 TAFLLPETRRTELPASTEEAE--GKRK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	136/525 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	95/382 (25%)
slc22a13a	XP_021322911.1	Sugar_tr	12..507	CDD:331684	134/523 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588898
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950