DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment QC and isoQC

DIOPT Version :9

Sequence 1:	NP_729109.1	Gene:	QC / 38663	FlyBaseID:	FBgn0052412	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_788550.1	Gene:	isoQC / 40270	FlyBaseID:	FBgn0036999	Length:	354	Species:	Drosophila melanogaster

Alignment Length:	303	Identity:	133/303 - (43%)
Similarity:	185/303 - (61%)	Gaps:	28/303 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DEVHFNRTLDSILVPRVVGSRGHQQVREYLVQSLNGLGFQTEVDEFKQRVPVFGELTFANVVGTI 101
            |::|....:|.||:|||||:..|..||||:||||..|.:..||:.|....|:.|:|.|.|::.|:
  Fly    60 DKLHLREAIDKILIPRVVGTTNHSIVREYIVQSLRDLDWDVEVNSFHDHAPIKGKLHFHNIIATL 124

  Fly   102 NPQAQNFLALACHYDSKYFPNDPGFVGATDSAVPCAILLNTAKTLGAYLQKEFR--NRSDVGLML 164
            ||.|:.:|.|:|||||||.|. ..|:||||||||||:|||.|:.    ||::.:  .:|.:.|||
  Fly   125 NPNAERYLVLSCHYDSKYMPG-VEFLGATDSAVPCAMLLNLAQV----LQEQLKPLKKSKLSLML 184

  Fly   165 IFFDGEEAFKEWTDADSVYGSKHLAAKLASKRSGSQAQLAPRNIDRIEVLVLLDLIGARNPKFSS 229
            :||||||||:||...||:||::|||.|...:          ..:|||::||||||:||.:|.|.|
  Fly   185 LFFDGEEAFEEWGPKDSIYGARHLAKKWHHE----------GKLDRIDMLVLLDLLGAPDPAFYS 239

  Fly   230 FYENTDGLHSSLVQIEKSLRTAGQLE----------GNNNMFLSR-VSGGLVDDDHRPFLDENVP 283
            |:|||:..:..:..:|..|.....||          .....|.|: :....::|||.|||..|||
  Fly   240 FFENTESWYMRIQSVETRLAKLQLLERYASSGVAQRDPTRYFQSQAMRSSFIEDDHIPFLRRNVP 304

  Fly   284 VLHLVATPFPDVWHTPRDNAANLHWPSIRNFNRVFRNFVYQYL 326
            :|||:..|||.|||||.|||:.:.:.:..|...:.|.|..:||
  Fly   305 ILHLIPVPFPSVWHTPDDNASVIDYATTDNLALIIRLFALEYL 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
QC	NP_729109.1	M28_QC_like	36..325	CDD:193501	131/300 (44%)
isoQC	NP_788550.1	M28_QC_like	56..346	CDD:193501	131/300 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445050
Domainoid	1	1.000	168	1.000	Domainoid score	I792
eggNOG	1	0.900	-	-		E1_KOG3946
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	41	1.000	Inparanoid score	I487
Isobase	1	0.950	-	0.861353	Normalized mean entropy	S1680
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D117458at50557
OrthoFinder	1	1.000	-	-		FOG0001509
OrthoInspector	1	1.000	-	-		mtm6584
orthoMCL	1	0.900	-	-		OOG6_102560
Panther	1	1.100	-	-	P	PTHR12283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1074
	12	11.750