DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and SV2A

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001315603.1	Gene:	SV2A / 9900	HGNCID:	20566	Length:	742	Species:	Homo sapiens

Alignment Length:	690	Identity:	116/690 - (16%)
Similarity:	208/690 - (30%)	Gaps:	278/690 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 ELEGLPESEQKNRGIPKKQDGSFENCFMYNVPYDSNATNDANQTRSPIPCNNGWIYDRKEVPYES 124
            |.:|:|.:|...:| .:..||:         |. :......:....| |...|....|||  .|.
Human    97 EYQGIPRAESGGKG-ERMADGA---------PL-AGVRGGLSDGEGP-PGGRGEAQRRKE--REE 147

  Fly   125 IATEYNWVCDKRDFGTYSVVVYFV----------------------------------------- 148
            :|.:|..:..:...|.:...:|||
Human   148 LAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVY 212

  Fly   149 -GCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIY 212
             |.:||...:|.:.|..||...|.::.|.:.:....|...:.:..|...|.::|:.:... :||.
Human   213 LGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGS-IPIV 276

  Fly   213 ------ILTLENVGIKYRTLVGNLA-LTFFFTLG---ACLLPWL-------------AYVISNWR 254
                  .|..|..|       .:|: |..|:.:|   |..:.|.             ||...:||
Human   277 FSYFSEFLAQEKRG-------EHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWR 334

  Fly   255 HYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEA----AKANG-----------KI 304
            .:.:|.|.|.||.|......||||.:.:..||.|....|:|:.    .:|.|           |.
Human   335 VFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKT 399

  Fly   305 ISEE---------------------------VWSEMRECYELKFANEQLGKQYTSLDLFKTFPRL 342
            |.:|                           ||.....|:         |.:|..:.|
Human   400 IHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCF---------GPEYRRITL------- 448

  Fly   343 VVLTILIVTWMTVALAYDA----------HVRVVE------------------------------ 367
                :::..|.|::.:|..          |::.|:
Human   449 ----MMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGG 509

  Fly   368 ----------------------------------------------ILDTDI------------- 373
                                                          ..:||:
Human   510 QYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINS 574

  Fly   374 ------------------------FITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAAS 414
                                    |::| |.:|..:|..||..||:|:|||..|::...::...|
Human   575 TFLHNKEGCPLDVTGTGEGAYMVYFVSF-LGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS 638

  Fly   415 SLFVGILKGHWNASTAAIAARF--FATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSP 477
            ..|:..  |:..::..|:...|  .:..::|.......|:.|:..|......:|.:.::.|:|..
Human   639 CFFLSF--GNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGI 701

  Fly   478 LVLSTH-RYYRPLPMFIITLVSVIGALIILFLPETKGATM 516
            .:.::. ...:..|:...:....:|:.:.|.||||:|..:
Human   702 SIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	116/690 (17%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	93/600 (16%)
SV2A	NP_001315603.1	synapt_SV2	1..742	CDD:130366	116/690 (17%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..144		12/58 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910