Protein Alignment CG5592 and SV2B

DIOPT Version :10

• Sequence 1: NP_647996.1
• Gene: CG5592 / 38662
• FlyBaseID: FBgn0035645
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_055663.1
• Gene: SV2B / 9899
• HGNCID: 16874
• Length: 683
• Species: Homo sapiens
• Alignment Length: 657
• Identity: 131/657 - (19%)
• Similarity: 210/657 - (31%)
• Gaps: 221/657 - (33%)

  Fly    62 EGLPESEQ----KNRGIPKKQDGSFENCFMYNVPYDS---------NATNDANQTRSPI-----P 108
            ||..|.::    :.:|||...|...:...|.....||         ....|..|.....     .
Human    37 EGHDEEDEIYEGEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDE 101

  Fly   109 CNNG---WIY----------DRKEVPYESIA---TEYNWVCDKRDFGTYSVVVYFVGCIVGCLCF 157
            |.:|   ||.          |..||...|.|   .|.:........|...::|| :|.:.|....
Human   102 CGHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVY-LGMMAGAFIL 165

  Fly   158 GFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIY-----ILTLE 217
            |.:.|..||...|.::.:.:.....:|...:.:..|...|.::|:.:......::     .|:.|
Human   166 GGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSRE 230

  Fly   218 NVGIKYRTLVGNLALTFFFTLG--ACLLPW-------------LAYVISNWRHYAMVVALPIVFM 267
            ..| ::.:.:|    .|:.|.|  |..:.|             ..|...:||.:.:|.|||....
Human   231 KRG-EHLSWLG----IFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVS 290

  Fly   268 ILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKAN--GKIISEEVWS--------EMRECYELKFA 322
            ::.....||||.:|:.:||.|....::|:....|  .|...|:|::        :|.|..|::
Human   291 MVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQ-- 353

  Fly   323 NEQLGKQYTS-LDLFKTF--------------PRLVVLTILIVTWMTVALAY------------- 359
             ...|..|.. |..|||.              |..:...||.|.|..:|.:|
Human   354 -SSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRY 417

  Fly   360 -------------------------------DAHVRVV-------------------------EI 368
                                           ..|.::|                         ::
Human   418 FQDEEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDV 482

  Fly   369 LDTD---------------------------------------------------IFITFSLSSL 382
            ..||                                                   |::...|.||
Human   483 TSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSL 547

  Fly   383 VEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASS--LFVGILKGHWNASTAAIA--ARFFAT--MA 441
            ..:|..|:..||:|||||..|:...||:.|...  ||.|      |:.:|.|.  ..|..|  .|
Human   548 SVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFG------NSESAMIGWQCLFCGTSIAA 606

  Fly   442 YNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTH-RYYRPLPMFIITLVSVIGALII 505
            :|.......|:.||..|.....|:|.:.:.||:|...:.::. ...:.:|:.:.....|.|.||.
Human   607 WNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIA 671

  Fly   506 LFLPETK 512
            |.||||:
Human   672 LRLPETR 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	MFS_SLC22	113..509	CDD:340875	113/580 (19%)
SV2B	NP_055663.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		2/4 (50%)
		synapt_SV2	8..683	CDD:130366	131/657 (20%)