DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and SV2B

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001309960.1	Gene:	SV2B / 9899	HGNCID:	16874	Length:	683	Species:	Homo sapiens

Alignment Length:	657	Identity:	131/657 - (19%)
Similarity:	210/657 - (31%)	Gaps:	221/657 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EGLPESEQ----KNRGIPKKQDGSFENCFMYNVPYDS---------NATNDANQTRSPI-----P 108
            ||..|.::    :.:|||...|...:...|.....||         ....|..|.....     .
Human    37 EGHDEEDEIYEGEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDE 101

  Fly   109 CNNG---WIY----------DRKEVPYESIA---TEYNWVCDKRDFGTYSVVVYFVGCIVGCLCF 157
            |.:|   ||.          |..||...|.|   .|.:........|...::|| :|.:.|....
Human   102 CGHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVY-LGMMAGAFIL 165

  Fly   158 GFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIY-----ILTLE 217
            |.:.|..||...|.::.:.:.....:|...:.:..|...|.::|:.:......::     .|:.|
Human   166 GGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSRE 230

  Fly   218 NVGIKYRTLVGNLALTFFFTLG--ACLLPW-------------LAYVISNWRHYAMVVALPIVFM 267
            ..| ::.:.:|    .|:.|.|  |..:.|             ..|...:||.:.:|.|||....
Human   231 KRG-EHLSWLG----IFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVS 290

  Fly   268 ILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKAN--GKIISEEVWS--------EMRECYELKFA 322
            ::.....||||.:|:.:||.|....::|:....|  .|...|:|::        :|.|..|::
Human   291 MVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQ-- 353

  Fly   323 NEQLGKQYTS-LDLFKTF--------------PRLVVLTILIVTWMTVALAY------------- 359
             ...|..|.. |..|||.              |..:...||.|.|..:|.:|
Human   354 -SSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRY 417

  Fly   360 -------------------------------DAHVRVV-------------------------EI 368
                                           ..|.::|                         ::
Human   418 FQDEEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDV 482

  Fly   369 LDTD---------------------------------------------------IFITFSLSSL 382
            ..||                                                   |::...|.||
Human   483 TSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSL 547

  Fly   383 VEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASS--LFVGILKGHWNASTAAIA--ARFFAT--MA 441
            ..:|..|:..||:|||||..|:...||:.|...  ||.|      |:.:|.|.  ..|..|  .|
Human   548 SVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFG------NSESAMIGWQCLFCGTSIAA 606

  Fly   442 YNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTH-RYYRPLPMFIITLVSVIGALII 505
            :|.......|:.||..|.....|:|.:.:.||:|...:.::. ...:.:|:.:.....|.|.||.
Human   607 WNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIA 671

  Fly   506 LFLPETK 512
            |.||||:
Human   672 LRLPETR 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	131/657 (20%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	104/539 (19%)
SV2B	NP_001309960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		2/4 (50%)
SV2B	NP_001309960.1	Sugar_tr	8..683	CDD:331684	131/657 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910