DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and SLC22A13

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_004247.2	Gene:	SLC22A13 / 9390	HGNCID:	8494	Length:	551	Species:	Homo sapiens

Alignment Length:	542	Identity:	153/542 - (28%)
Similarity:	252/542 - (46%)	Gaps:	54/542 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KYENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELE----GLPESE 68
            ::...|..|||||.||.:||..:....||..|.:|..:||: |.:.|.|.|..::    .|..:|
Human     3 QFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMV-LDEPHHCAVAWVKNHTFNLSAAE 66

  Fly    69 QKNRGIPKKQDGSFENCFMYNVPYDSNATNDA-----NQTRSPIPCNNGWIYDRKEVPYESIATE 128
            |....:|....|..|.|.|:..|..:.:..|.     |:|:   ||:.||.|....:|  |:..|
Human    67 QLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQ---PCDMGWEYPENRLP--SLKNE 126

  Fly   129 YNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCF 193
            :|.|||::.....:..|:..|.:||.|.||.:.|..||...:........:.|..:.....|..:
Human   127 FNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELY 191

  Fly   194 AASRF-----VAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNW 253
            .|.||     |||||    |..:.:|| |.||..:||....|| ...|:||..:|..|||...||
Human   192 MALRFAVATAVAGLS----FSNVTLLT-EWVGPSWRTQAVVLA-QCNFSLGQMVLAGLAYGFRNW 250

  Fly   254 RHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYE 318
            |...:....|.:.:.......|||..||::.|::|..|:::::||..|.:.:|.|:.:::
Human   251 RLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQL----- 310

  Fly   319 LKFANEQLGKQYTSLDLFKTFPRLVVLTILI-VTWMTVALAYDAHVRVVEILDTDIFITFSLSSL 382
               ..|:.|....:||||: .|:|..:|::| ..|...:|.|......|.....|:::|..:...
Human   311 ---VPEKTGPSGNALDLFR-HPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGA 371

  Fly   383 VEIPAGIVPMLLLDRIGRK----------PMMSAVMLLCAASSLFVGILKGHWNASTAAIAARFF 437
            ||:||....:.::.|.|||          .:|..:::...|....|        .:..|:..:..
Human   372 VEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVV--------VTMLAVVGKMA 428

  Fly   438 ATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGA 502
            ...|:.:...:::|:.||:||..|:.::.|..::|.:|:|||:....|:..|||.|...:.::..
Human   429 TAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAG 493

  Fly   503 LIILFLPETKGATMPQTLDEAE 524
            |:...||||.|..:..||.:.|
Human   494 LLCTLLPETHGQGLKDTLQDLE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	148/526 (28%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	101/383 (26%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	148/526 (28%)
		MFS	139..500	CDD:119392	101/383 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153617
Domainoid	1	1.000	65	1.000	Domainoid score	I10025
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4003
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.800