Protein Alignment CG5592 and SLC22A14

DIOPT Version :10

• Sequence 1: NP_647996.1
• Gene: CG5592 / 38662
• FlyBaseID: FBgn0035645
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_006713479.2
• Gene: SLC22A14 / 9389
• HGNCID: 8495
• Length: 675
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 160/582 - (27%)
• Similarity: 263/582 - (45%)
• Gaps: 93/582 - (15%)

  Fly     7 EKYENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVREL----EGLPES 67
            :|:.|.|..:|:||.||:||:......:.:.||..|...|:....| .:|....:    ..|.::
Human   131 DKFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQK-PYCNTSWILAVGPHLSKA 194

  Fly    68 EQKNRGIPKKQDGSFENCFMY-NVPY--DSNATNDANQTRSPIPCNNGWIY-DRKEVPYESIATE 128
            ||.|..||:..:|||..|||| .||:  ||......|.|.:   |.:|||| |.|:   .|:..|
Human   195 EQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDT---CQDGWIYPDAKK---RSLINE 253

  Fly   129 YNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCF 193
            ::.||........:.:::..|..:|.|.|..|||..||.||:.|:....:|.|..:.....|..:
Human   254 FDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLY 318

  Fly   194 AASRFVAGLS---MNYCFVPIYILTLENVGIKYRT---LVGNLALTFFFTLGACLLPWLAYVISN 252
            ...||  |:|   :.|....|.:.|...|| ::|.   ::|:.    ||.:||.||..:||.:.:
Human   319 LFFRF--GISQSVVGYAISSISLATEWLVG-EHRAHAIILGHC----FFAVGAVLLTGIAYSLPH 376

  Fly   253 WRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECY 317
            |:...:|..:.::..|....:.||||.|||..|||....:|:..||..|.|.|...:..|:
Human   377 WQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDEL---- 437

  Fly   318 ELKFANEQLGKQYTS----LDLFKTFPRLVVLTILIVTWMTVALAY-DAHVRVVEILDTDIFITF 377
                   ||.::..:    ||..|......|..::...|.||:..| ...:|:.| |...:....
Human   438 -------QLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRE-LGVSVHFRH 494

  Fly   378 SLSSLVEIPAGIVPMLLLDRIGRKPMMSAVML------------------------LCAASSL-- 416
            .:.|::|:||.:..:.||.:||||..::..:|                        .|.|:.|
Human   495 VVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKS 559

  Fly   417 ---FVGILKGHWNASTAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPL 478
               .|.:|:   ..|.||....||.         :.:|:||||||..||.::::....||:||..
Human   560 MTILVLMLR---EFSLAATVTVFFL---------YTAELLPTVLRATGLGLVSLASVAGAILSLT 612

  Fly   479 VLSTHRYYRP--LPMFIITLVSVIGALIILFLPETKGATMPQTLDEAEKRWTLRCRDRKINE 538
            ::|    ..|  ||:|:..:::::...:...||||:...:.::|:.:.:... :.:|.|..|
Human   613 IIS----QTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIRN-KVKDMKTKE 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	MFS_SLC22	113..509	CDD:340875	115/438 (26%)
SLC22A14	XP_006713479.2	MFS_OAT	229..641	CDD:340932	119/452 (26%)