DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and SLC22A8

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001171661.1	Gene:	SLC22A8 / 9376	HGNCID:	10972	Length:	542	Species:	Homo sapiens

Alignment Length:	511	Identity:	144/511 - (28%)
Similarity:	246/511 - (48%)	Gaps:	49/511 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QIFMILLPKNHWCRVRELEGLPESEQKNRG---IPKKQDGSFENCFMYNVPYDSNATNDANQTRS 105
            |||....|.:| ||        .....:.|   :|...:|..|.|..:..|.:::..||..  |:
Human    38 QIFTAATPVHH-CR--------PPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQ--RA 91

  Fly   106 PIPCNNGWIYDRKEVPYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPAL 170
            ..||.:||:|:..:   :||.||::.||:.......:..::..|.::|.|..|.::|..||.|.|
Human    92 MEPCLDGWVYNSTK---DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPIL 153

  Fly   171 FLANSCSMI----GGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLA 231
                :||.:    .|..:.....||.:...||:.|..::...:...||.:|.|..:.|.:: :.|
Human   154 ----TCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIM-STA 213

  Fly   232 LTFFFTLGACLLPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKE 296
            |.:.:|.|..:||.|||.|..||...:.|::|.....|:|...|||..||:..||..:.:::::.
Human   214 LGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRR 278

  Fly   297 AAKANGKIISEEVWSEMRECYELKFANEQ---LGK-QYTSLDLFKTFPRLVVLTI-LIVTWMTVA 356
            .|..|||  .||  .|.....|||...::   |.| :||:.|||: .|.|..:|. |.:.|....
Human   279 VAVFNGK--KEE--GERLSLEELKLNLQKEISLAKAKYTASDLFR-IPMLRRMTFCLSLAWFATG 338

  Fly   357 LAYDAHVRVVEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSL---FV 418
            .||.:....||....:::|...:...|::||..:.:|.|..:||....:|.:||...:.|   ||
Human   339 FAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFV 403

  Fly   419 GILKGHWNASTA----AIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLV 479
            .:     :..|.    |:..:...:.:::....:.||:.|||:|..|:.:.|:..::|:::||||
Human   404 PL-----DLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLV 463

  Fly   480 LSTHRYYRPLPMFIITLVSVIGALIILFLPETKGATMPQTLDEAEKRWTLRCRDRK 535
            ..|......:|..|..:.:::|....||||||....:|:|:::.| .|:||.:..|
Human   464 KITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLE-NWSLRAKKPK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	138/493 (28%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	106/383 (28%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	138/493 (28%)
		MFS	96..493	CDD:119392	115/414 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..542		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153801
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950