DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and SLC22A16

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens

Alignment Length:	571	Identity:	134/571 - (23%)
Similarity:	250/571 - (43%)	Gaps:	89/571 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFT-------YFGQIFMILLPKNHWCR--------- 57
            :|.....:|.||.|| |:|:      |:.||.       |...:||.:.| :|.||
Human     6 FEGIYDHVGHFGRFQ-RVLY------FICAFQNISCGIHYLASVFMGVTP-HHVCRPPGNVSQVV 62

  Fly    58 --------VRELEGLPESEQKNRGIPKKQDG---SFENCFMYNVPYDSNATNDANQTRSPIPCNN 111
                    :.:...|..|.||:....:.|:|   ....|........|:...:...::...||.:
Human    63 FHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVD 127

  Fly   112 GWIYDRKEVPYESIA-TEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANS 175
            |:|||:.  .::|.| |::|.|||::........::..|.::|.:.||:.:|..||...|:..:|
Human   128 GYIYDQN--TWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSS 190

  Fly   176 CSMIGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGA 240
            ...:.|..:....|:..|.|:||...:..:...|..::..:|.:|:|.||. .::.|..||.:|.
Human   191 SMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW-ASVHLHSFFAVGT 254

  Fly   241 CLLPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKII 305
            .|:....|::..|..|.|:::...|..||...:.||:|.||:|.|:.:...:::...||
Human   255 LLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAK------ 313

  Fly   306 SEEVWSEMRECYELKFANEQLGKQYTSLDL---FKTFPRLV-----------------VLTILIV 350
                |:....|   |.:      :..||||   ....|..|                 .||:.::
Human   314 ----WNRASSC---KLS------ELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLI 365

  Fly   351 TWMTVALA-YDAHVRVVEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAAS 414
             |.|.:|. |...:..|. |..:.::...|..:|||||.....:.:|::||:.:: |..|.|  |
Human   366 -WFTGSLGFYSFSLNSVN-LGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVL-AYSLFC--S 425

  Fly   415 SLFVGIL-----KGHWNASTAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGAL 474
            :|..|::     |.:......|:..:|....|:.:...:.:|:.||::|...:...:::.::.::
Human   426 ALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASI 490

  Fly   475 LSPLVLSTHRYYRPLPMFIITLVSVIGALIILFLPETKGATMPQTLDEAEK 525
            |:|..:.....:..:|...:..::::..::.|.||||.|..:..|.:||.|
Human   491 LAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAK 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	129/555 (23%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	86/393 (22%)
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	129/555 (23%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153552
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850