DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and slc22a7a

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001077330.1	Gene:	slc22a7a / 794188	ZFINID:	ZDB-GENE-050506-52	Length:	560	Species:	Danio rerio

Alignment Length:	560	Identity:	156/560 - (27%)
Similarity:	272/560 - (48%)	Gaps:	43/560 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KYENFLLFIGDFGPFQKRLLF--WM----MPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGL-- 64
            ::|:.|..||.|..||..:|:  |:    :|..||.      ..|:..:|.:| |.:..|:|.
Zfish     2 RFEDVLREIGGFNKFQFLVLYILWLPRVILPLHFLL------HNFISGVPPHH-CALPRLDGRFS 59

  Fly    65 ---PESEQKNR----GIPKKQDGSFENCFMYNVPYDSNATND-----ANQTRSPIPCNNGWIYDR 117
               .|.|:..:    |||:..|||:.:|.||.:|.|.:...|     .|::...:||.|||:|||
Zfish    60 ASGAEKEELAQIVALGIPRNSDGSYSSCKMYTMPMDFDLNGDLSVLYGNRSNVSVPCQNGWVYDR 124

  Fly   118 KEVPYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGC 182
            .:.. .:.|||::.|||.:.........:|:|..:|.:.||.::|..||.|.:.::...|.:.|.
Zfish   125 SQFT-STTATEWDLVCDNKKLNQALATFFFIGVTMGAVVFGQLSDKFGRKPMIQVSFVSSAVFGI 188

  Fly   183 VSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLA 247
            :......:..||.:|.:.|.::....:....|.:|...:|:||..|.: ::..:::|..||..||
Zfish   189 IEAFSSSYVMFAIARTLCGFALTGMSITTVALCVEWTDVKHRTFTGTI-ISLGWSVGNMLLALLA 252

  Fly   248 YVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSE 312
            |:|.:|||..:||..|.:..|:.....|||..||::.|:|:...:.:...||.|||.    .:::
Zfish   253 YLIRDWRHLILVVTSPCLVGIIAWWWIPESARWLLANGRVEEAQKYLINCAKMNGKY----SYTK 313

  Fly   313 MRECYELKFAN--EQLGKQYTSLDLFKTFPRLVVLTILI-VTWMTVALAYDAHVRVVEILDTDIF 374
            ..:...||...  |...|.::.|||.:| |:|..:.:.. :.|..||..|......:.....:|:
Zfish   314 KLDIENLKKITIAEDSNKNHSYLDLVRT-PKLRKIVLCSGIFWFAVAFTYYGISFNITGFGLNIY 377

  Fly   375 ITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKGHWNASTAAIA--ARFF 437
            :|..:..::|:||.:...|.||||||:...:..:::..|......::...:.|....||  .:.|
Zfish   378 LTQFIYGVIEVPAKVGTYLTLDRIGRRNGQAWSLIIAGALIGLNSVIPTEFAAVRTGIAVIGKGF 442

  Fly   438 ATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGA 502
            :..|:.:...:.||:.|||||..||...:.:.::|..|:|:|:.....:...|..:.:..:|...
Zfish   443 SEAAFTIAFLYTSELYPTVLRQCGLGYTSFIARIGGSLAPMVILFEDIWHYGPPVVFSATAVFSG 507

  Fly   503 LIILFLPETKGATMPQT-LDEAEKRWTLRC---RDRKINE 538
            .::..||||....:|:. ||..|.|.||..   ||.::||
Zfish   508 CVVFLLPETTNVQLPENILDVEEGRHTLSTEAERDVELNE 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	143/526 (27%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	94/372 (25%)
slc22a7a	NP_001077330.1	2A0119	11..523	CDD:273328	142/525 (27%)
slc22a7a	NP_001077330.1	MFS	148..514	CDD:119392	94/371 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589025
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860