DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5592 and slc22a15.2

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001039179.1	Gene:	slc22a15.2 / 734018	XenbaseID:	XB-GENE-5824718	Length:	487	Species:	Xenopus tropicalis

Alignment Length:	521	Identity:	127/521 - (24%)
Similarity:	219/521 - (42%)	Gaps:	68/521 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LFIGDFGPFQKRLLFWMMPAAFLFAFTYF--GQIFMILLPKNHWCRVRELEGLPESEQKNRGIPK 76
            |:||:||..||||      .|||.....:  .|..:|:|          :..:||
Frog     8 LYIGEFGCCQKRL------TAFLTLLQVYVACQSMLIVL----------VGAVPE---------- 46

  Fly    77 KQDGSFENCFMYNVPYDSNATNDANQTRSPIPCNNGWIYDRKEVPYESIATEYNWVCDKRDFGTY 141
                       |.:..:..:.:....|:.....||          :.||.:|::.:.::......
Frog    47 -----------YLIDNEDISASKEEYTKHLHDTNN----------FTSIVSEWHLIKNEAYKVNL 90

  Fly   142 SVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFVAGLSMNY 206
            :..::|.|.::|.:.||.::|..||.|.........:..|..:.:...:..||.|||..|:....
Frog    91 ASSLFFAGLLIGNILFGPLSDKLGRRPVYLSGLFFDITFGYCTALAPSYEVFAVSRFFVGIMNGG 155

  Fly   207 CFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYAMVVALPIVFMILTS 271
            ..:..::||.|.||..|..|.|:|. ...|.:|......|.:.|.|||..|.|...|.:|..|.|
Frog   156 MALVSFVLTQEYVGKSYWALTGSLT-NLIFAVGIAFYALLGFYIRNWRTLAFVANSPGIFFFLLS 219

  Fly   272 LLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYELKFANEQLGKQYTSLDLF 336
            .|.||||.||.|.|.......|::..|..||   .|....:::.|     ........::..||.
Frog   220 FLLPESPRWLYSHGYTTEAEGVLQSMAVGNG---VERPVVKLKSC-----PGTSSKSAHSVFDLV 276

  Fly   337 KTFPRLVVLTILIV-TWMTVALAYDAHVRVVEILDTDIFITFSLSSLVEIPAGIVPMLLLDR--I 398
            | :..|...|||:: .|...:|.|.........|..::::..:|..|||:||..:.:..:::  .
Frog   277 K-YGVLRWRTILLMYIWYVCSLVYYGLTLNAGELKGNLYLNVALYGLVEVPAFPLCLYFIEKSWS 340

  Fly   399 GRKPMMSAVMLLCAASSLFVGIL---KGH-WNASTAAIAARFFATMAYNVGQQWASEILPTVLRG 459
            ||:...:..:.....:.:|...|   .|. .|.:..|:..:...:.|:||...:.||:.|||:|.
Frog   341 GRRKATAGFLGFAGFACIFTIFLPETNGDLLNPTVLALFGKLSVSAAFNVVYIYTSELYPTVVRN 405

  Fly   460 QGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGA-LIILFLPETKGATMPQTLDEA 523
            .||.:..:..:.|.:|||.: .|.:...|...|:...:|.|.| ::.|.||||:...:.:::::.
Frog   406 AGLGVCAMACRFGGILSPFI-PTMKSLNPSMPFVAFGISGISAGILSLLLPETRNKPIAESIEDL 469

  Fly   524 E 524
            :
Frog   470 Q 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	125/511 (24%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	99/375 (26%)
slc22a15.2	NP_001039179.1	MFS	48..455	CDD:391944	105/427 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920