Protein Alignment CG5592 and SLC22A5

DIOPT Version :10

• Sequence 1: NP_647996.1
• Gene: CG5592 / 38662
• FlyBaseID: FBgn0035645
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001295051.1
• Gene: SLC22A5 / 6584
• HGNCID: 10969
• Length: 581
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 144/553 - (26%)
• Similarity: 270/553 - (48%)
• Gaps: 48/553 - (8%)

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFL-FAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKNR 72
            |:....|:|::|||| ||:|:::.|:.: ..||....:|:|..|: |.|||.:...| .|..:|.
Human     4 YDEVTAFLGEWGPFQ-RLIFFLLSASIIPNGFTGLSSVFLIATPE-HRCRVPDAANL-SSAWRNH 65

  Fly    73 GIP-KKQDGSF--ENCFMYNVPYDSNATN---------DANQTRSPIPCNNGWIYDRKEVPYESI 125
            .:| :.:||..  .:|..|.:...:|.:.         |..|.... .|.:||.:. ::|...:|
Human    66 TVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQE-SCLDGWEFS-QDVYLSTI 128

  Fly   126 ATE------------------------YNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGR 166
            .||                        :|.||:.......::.::|||.::|....|.::|..||
Human   129 VTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGR 193

  Fly   167 LPALFLANSCSMIGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLA 231
            ...||:..........:.:..|:|..|.....:.|:.....:|..::|..|.:|...|.:...|.
Human   194 KNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLG 258

  Fly   232 LTFFFTLGACLLPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKE 296
            :..|:..|..:||..||.|.:||...:.:.:|.|..:......||||.||:|.|:.:....::::
Human   259 VCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRK 323

  Fly   297 AAKANGKIISEEVWSEMRECYELKFANEQLGKQYTSLDLFKTFPRLVVLTILIVTWMTVALAYDA 361
            ||||||.::...::...    ||:..:.:..:.:..|||.:|:...:|..:.|:.|||:::.|..
Human   324 AAKANGIVVPSTIFDPS----ELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG 384

  Fly   362 HVRVVEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKG--H 424
            .......|..|||:...||::||:||.::..|||..:.|:..|:..:.|..:..||:.::..  :
Human   385 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLY 449

  Fly   425 WNASTAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPL 489
            :.|:...:..:|..|.|:::...:.:|:.|||:|..|:.:.:...::|::|||..:....|.|.|
Human   450 YLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFL 514

  Fly   490 PMFIITLVSVIGALIILFLPETKGATMPQTLDE 522
            |..::..::::.|::.|||||:.|..:|.|:|:
Human   515 PYILMGSLTILTAILTLFLPESFGTPLPDTIDQ 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	MFS_SLC22	113..509	CDD:340875	104/421 (25%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	140/540 (26%)