DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and SLC22A4

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_003050.2	Gene:	SLC22A4 / 6583	HGNCID:	10968	Length:	551	Species:	Homo sapiens

Alignment Length:	536	Identity:	138/536 - (25%)
Similarity:	264/536 - (49%)	Gaps:	29/536 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFL-FAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKNR 72
            |:..:.|:|::|||| ||:|:::.|:.: ..|.....:|:...|: |.|||.:...| .|..:|.
Human     4 YDEVIAFLGEWGPFQ-RLIFFLLSASIIPNGFNGMSVVFLAGTPE-HRCRVPDAANL-SSAWRNN 65

  Fly    73 GIP-KKQDGSF--ENCFMYNVPYDSNATN---------DANQTRSPIPCNNGWIYDRKEVPYESI 125
            .:| :.:||..  .:|..|.:...:|.:.         |..|.... .|.:||.:. ::|...::
Human    66 SVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQE-SCLDGWEFS-QDVYLSTV 128

  Fly   126 ATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDF 190
            .||:|.||:.......:..::|||.::|....|.::|..||...||...:.......:.:....:
Human   129 VTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISW 193

  Fly   191 PCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRH 255
            ..|.....:.|:.....:|..:||..|.:|...|.:...|.:..||.:|..|||..||.|.:||.
Human   194 EMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRM 258

  Fly   256 YAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYELK 320
            ..:.:.:|.|..:......||||.||:|..:.....:::::|||.|...:...::..:.|...||
Human   259 LLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLK 323

  Fly   321 FANEQLGKQYTSLDLFKTFPRLVVLTIL-IVTWMTVALAYDAHVRVVEILDTDIFITFSLSSLVE 384
                  .::...||||:| ..:.::||: ::.||..::.|.|.......|..|.::...||:|:|
Human   324 ------QQKAFILDLFRT-RNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIE 381

  Fly   385 IPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKGHWNASTAAIA--ARFFATMAYNVGQQ 447
            |||.|...|||..:.|:.:::||:.......||:.::...:...:..:.  .:|..|.|:::...
Human   382 IPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYV 446

  Fly   448 WASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIILFLPETK 512
            :.:|:.||::|...:.:.:...::|::::|..:....|.|.||..::..::|:..::.||.||:.
Human   447 FTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESL 511

  Fly   513 GATMPQTLDEAEK-RW 527
            |.|:|:||::.:| :|
Human   512 GMTLPETLEQMQKVKW 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	132/517 (26%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	91/370 (25%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	132/517 (26%)
SLC22A4	NP_003050.2	MFS	123..508	CDD:119392	97/391 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153717
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850