Protein Alignment CG5592 and SLC22A3

DIOPT Version :10

• Sequence 1: NP_647996.1
• Gene: CG5592 / 38662
• FlyBaseID: FBgn0035645
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 157/548 - (28%)
• Similarity: 271/548 - (49%)
• Gaps: 48/548 - (8%)

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCR------VRELEGLPES 67
            ::..|..:|:||.||:|:...:......|||.:.|.:|:...|.::|||      :.|..|....
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPE 68

  Fly    68 EQKNRGI-------PKKQDGSFENCFMYNVPYDSNATNDA-----------NQTRSPIPCNNGWI 114
            |:.||..       |.::.|..:. ::.....||.:...|           |::...:||..||.
Human    69 EEWNRTAPASRGPEPPERRGRCQR-YLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWR 132

  Fly   115 YDRKEVPYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMI 179
            |.:   .:.:|.:|::.||........:..:..:|.:.|....|:..|..||:....|  ||..:
Human   133 YAQ---AHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLL--SCLGV 192

  Fly   180 G--GCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACL 242
            |  |.|.....:||.|...||:.|:.....::..|::..|.||.|.|.:|| :.:..|||||..:
Human   193 GVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVG-IVIQMFFTLGIII 256

  Fly   243 LPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISE 307
            ||.:||.|.||:...:.:.||....:|...:.||||.||::..|.|:.:::::..||.|||.:|.
Human   257 LPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSS 321

  Fly   308 EVWSEMRECYELKFANEQLGKQYTSLDLFKTFPRLVVLT-ILIVTWMTVALAYDAHVRVVEILDT 371
            ..       .|:...:|::... :.|||.:| |::...| ||:..|.|.|:.|...|..:.|:..
Human   322 NY-------SEITVTDEEVSNP-SFLDLVRT-PQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGG 377

  Fly   372 DIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGIL-KG-HWNASTAAIAA 434
            :::|.|.:|.:||:|..::.:|.::|:||:...:|..::...:.|....| :| .|..:|.|...
Human   378 NLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLG 442

  Fly   435 RFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSP-LVLSTHRYYRPLPMFII-TLV 497
            |...|||:.:.....||:.||.||..|:::.:.:...|.:::| |:......:..||:.|. .|.
Human   443 RLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILA 507

  Fly   498 SVIGALIILFLPETKGATMPQTLDEAEK 525
            |:.|.|::| ||||||..:|:|:|:.||
Human   508 SICGGLVML-LPETKGIALPETVDDVEK 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	MFS_SLC22	113..509	CDD:340875	116/402 (29%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	152/532 (29%)
		Proline-rich sequence. /evidence=ECO:0000305|PubMed:26979622	289..293		3/3 (100%)