Protein Alignment CG5592 and SLC22A1

DIOPT Version :9

• Sequence 1: NP_647996.1
• Gene: CG5592 / 38662
• FlyBaseID: FBgn0035645
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 149/570 - (26%)
• Similarity: 242/570 - (42%)
• Gaps: 91/570 - (15%)

  Fly    10 ENFLLFIGDFGPFQKR--LLFWMMPAAFLFAFTYFGQIFMILLPKNHWCR---VRELE---GLPE 66
            ::.|..:|:.|.|||:  |:..::.||  ||....|.:|:...|.:| |:   |.||.   |...
Human     5 DDILEQVGESGWFQKQAFLILCLLSAA--FAPICVGIVFLGFTPDHH-CQSPGVAELSQRCGWSP 66

  Fly    67 SEQKNRGIP---KKQDGSFENCFMYNVPYDSNATN--------DANQTRSPI-PCNNGWIYDRKE 119
            :|:.|..:|   ...:.....|..|.|.::.:|.:        ..|::..|: ||.:||:||
Human    67 AEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYD--- 128

  Fly   120 VPYESIATEYNWVCD---KRDFGTYSVVVYFVGC-----IVGCLCFGFITDHSGRLPALFLANSC 176
            .|..||.||:|.||.   |.|.        |..|     :.|.|..|:..|..||...|......
Human   129 TPGSSIVTEFNLVCADSWKLDL--------FQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLV 185

  Fly   177 SMIGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGAC 241
            :.:.|.:.....::......|.:.||.....::..|.|..|.||...|..|. :.....||:|..
Human   186 NAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVA-IMYQMAFTVGLV 249

  Fly   242 LLPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKI-- 304
            .|..|||.:.:||...:.|:||....:|.....||||.||:|..:....|::|...|:.|||:
Human   250 ALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPP 314

  Fly   305 -------ISEEVWSEMRECYELKFANEQLGKQYTSLDLFKTFPRLVVLT-ILIVTWMTVALAYDA 361
                   :.|:|             .|:|...:.  |||:| |||...| ||:..|.|.::.|..
Human   315 ADLKMLSLEEDV-------------TEKLSPSFA--DLFRT-PRLRKRTFILMYLWFTDSVLYQG 363

  Fly   362 HVRVVEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKG--H 424
            .:..:.....::::.|..|:|||||...:.::.:||:||...|:...||..|:.|.:..:..  |
Human   364 LILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLH 428

  Fly   425 WNASTAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSP-LVLSTHRYYRP 488
            |.........|...|:|..:.....:|:.||.:|..|:.:.:.:..:|.:::| :|......::.
Human   429 WLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQA 493

  Fly   489 LPMFIITLVSVIGALIILFLPETKGAT------MPQTLDEAEKRWTLRCR 532
            ||             :|||..::...|      .||.....|:....|||
Human   494 LP-------------LILFEKQSPKKTRFTLRSKPQNPRAPERDVLRRCR 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	143/548 (26%)
		MFS	141..509	CDD:119392	97/385 (25%)
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	139/530 (26%)
		MFS	118..484	CDD:119392	107/393 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153746
Domainoid	1	1.000	61	1.000	Domainoid score	I10516
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950