Protein Alignment CG5592 and SLC22A23

DIOPT Version :9

• Sequence 1: NP_647996.1
• Gene: CG5592 / 38662
• FlyBaseID: FBgn0035645
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_011513103.1
• Gene: SLC22A23 / 63027
• HGNCID: 21106
• Length: 710
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 141/610 - (23%)
• Similarity: 250/610 - (40%)
• Gaps: 125/610 - (20%)

  Fly     9 YENFLL-FIGDF-GPFQKR--LLFWMMPAAFLFAFTYFGQIFMILLPKNHWCR----VRELEGLP 65
            |:..:| |:|.. |.:||.  ||.| :||.|: .|:.|...|::..| |.|||    ..||.|:.
Human    80 YDGSVLPFLGGLGGGYQKTLVLLTW-IPALFI-GFSQFSDSFLLDQP-NFWCRGAGKGTELAGVT 141

  Fly    66 ESEQKNRGIPKKQDGSFENCFMYNVPYDSNATNDANQTRS------PIP-----------CN-NG 112
            .:   .||.......|.........|::: |.|.:|.:.:      |:|           |: ..
Human   142 TT---GRGGDMGNWTSLPTTPFATAPWEA-AGNRSNSSGADGGDTPPLPSPPDKGDNASNCDCRA 202

  Fly   113 WIY------------------DRKEVPYESIA----TEYNW--VCD---KRDFGTYSVVVYFVGC 150
            |.|                  :...:|:::..    .|.||  |||   |.....:|::   ||.
Human   203 WDYGIRAGLVQNVVSKCCQQQETGALPWDTDTKRWRPELNWDLVCDNAWKVHIAKFSLL---VGL 264

  Fly   151 IVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILT 215
            |.|.|..|.|.|..||.|.|..:....:|.|....:..:...|:..||..|..:....:.:|.|.
Human   265 IFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALR 329

  Fly   216 LENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSW 280
            :|......|.:: .:..:|....|..|:|.||.:..:|:....::..|.:.|:|...:.|||..|
Human   330 IELCPPGKRFMI-TMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRW 393

  Fly   281 LMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYELKFANEQLGKQYT-------------S 332
            ||:..:.:....::....:.|          .|....::|....:|.|:.:             :
Human   394 LMATQQFESAKRLILHFTQKN----------RMNPEGDIKGVIPELEKELSRRPKKVCIVKVVGT 448

  Fly   333 LDLFKTFPRLVVLTILIVTWMTV-------ALAYDAHVRVVEILDTDIFITFSLSSLVEIPAGIV 390
            .:|:|   .:|||.:..:|...:       .:.::..|.::|....|.:.|.|: :||...|..|
Human   449 RNLWK---NIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASI-ALVSCLAMCV 509

  Fly   391 PMLLLDRIGRKPMMSAVMLLCAASSLF-VGILK--GHW-----NASTAAIAARFFATMAYNVGQQ 447
            .:..|   ||:..:...|:|.|.:||. :|:|.  |.:     :..:.::..:|  ::|:::...
Human   510 VVRFL---GRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKF--SIAFSIVGM 569

  Fly   448 WAS------------EILPTVLRGQGLAIINIMGQMGALLSPLV-LSTHRYYRPLPMFIITLVSV 499
            :||            ||.|||:|..||.::......|.|.:|:: |...:.|. |...|....::
Human   570 FASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYF-LHHIIFACCTL 633

  Fly   500 IGALIILFLPETKGATMPQTLDEAE 524
            |..:.||.|||::...:|:.:...|
Human   634 ICIICILLLPESRDQNLPENISNGE 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	137/594 (23%)
		MFS	141..509	CDD:119392	92/408 (23%)
SLC22A23	XP_011513103.1	2A0119	<243..652	CDD:273328	100/432 (23%)
		MFS	259..>388	CDD:119392	33/132 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940